depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. th...

kelussia odoratissima mozaff. is an iranian endangered endemic edible plant with enormous use in the middle region of iran as food and spice especially yogurt seasoning, and as medicinal herb for anti-inflammatory and cardiovascular purposes. antioxidant, anti-inflammatory, antihyperlipidemic properties of kelussia suggest that it may have beneficial effects on inflammatory bowel diseases like ...

Methanol extract of dried leaves of Momordica charantia Linn ( Cucurbitaceae ) was investigated for anxiolytic, antidepressant and anti-inflammatory activities in animal models. Anxiolytic activity of methanol extract of dried leaves of Momordica charantia Linn was tested by elevated plus maze test and the results showed a significant anxiolytic effect comparable, with diazepam in all the t...

objective(s): occludin is essential for proper assembly of tight junctions (tjs) which regulate paracellular endothelial permeability. omega-3 polyunsaturated fatty acids (ω-3 pufa) protect endothelial barrier function against injury. materials and methods: we examined anti-inflammatory effect of ω-3 pufa intake (30 mg/kg/day for 10 days) on expression and location of occludin in the aorta of a...

background and aims: plants as medicines have always played a vital role in human life. tumor necrosis factor alpha (tnf)-α is one of the macrophage-derived inflammatory cytokine with pleotropic effects in the inflammation process. some studies have been demonstrated that some of the echinops species have anti-inflammatory activity. in fact, echinops lasilepis is introduced as one of the native...

The aim of the present study was to investigate the potential of nanoemulsion formulation for topical delivery of Clobetasol propionate (CP) using algal oil (containing omega-3 fatty acids) as the oil phase. CP has anti-inflammatory, immunomodulatory and antiproliferative activities. However, its clinical use is restricted to some extent due to its poor permeability across the skin. Algal oil w...

The aim of the present study was to investigate the potential of nanoemulsion formulation for topical delivery of Clobetasol propionate (CP) using algal oil (containing omega-3 fatty acids) as the oil phase. CP has anti-inflammatory, immunomodulatory and antiproliferative activities. However, its clinical use is restricted to some extent due to its poor permeability across the skin. Algal oil w...

Hydrocotyle umbellata L. (Family Araliaceae) populary known as Acaricoba, is indicated in folk medicine for treatment of several inflammatory disorders. The goal of the present study is to evaluate the anti-inflammatory activity of the defatted ethanolic extract (DEE) of the aerial parts using carrageenan-induced rat paw oedema method. The levels of the pro-inflammatory cytokine interl...

Drug delivery across the skin is used for several millennia to ease gastrointestinal (GI) ailments in Traditional Persian Medicine (TPM). TPM topical remedies are generally being applied on the stomach, lower abdomen, lower back and liver to alleviate GI illnesses such as dyspepsia, gastritis, GI ulcers, inflammatory bowel disease, intestinal worms and infections. The aim of the present study i...

Withania somnifera an Indian traditional medicinal herb, is known to possess antistress, antioxidant, analgesic, anti-inflammatory, cardioprotective, adaptogenic, antispasmodic, immunomodulatory and immunostimulant activities. Its other activities include anti-inflammatory, immunoregulatory, anti-tumor, anti-angiogenic, antiinvasive and chemopreventive effects. We investigated the antioxidant, ...