Extracts of the brain/corpora cardiaca/corpora allata (Br/CC/CA) complex of Manduca sexta larvae elicit an antidiuretic effect, measured by an increase in fluid reabsorption across the cryptonephric complex of larval M. sexta. Separation of the extract by reversed-phase liquid chromatography gave two fractions with antidiuretic effects. The more potent of these two factors was further character...

1. Congestive heart failure was induced in dogs by rapid pacemaker stimulation of the heart (240-280/min) for 14 days. This represents a model of low output heart failure which permits the study of the development and reversal of congestive heart failure in an anatomically intact circulation in the unanaesthetized animal. 2. Cardiac output was reduced by 54%. Pulmonary artery pressure gradually...

Neurological involvement of the central nervous system in brucellosis is uncommon. We describe a rare case of meningoencephalitis due to Brucella melitensis infection, associated with the syndrome of inappropriate antidiuretic hormone secretion and leading to diabetes insipidus and hypothyroidism. Neurobrucellosis, although rare, should be considered in cases of neurological disease of unknown ...

chogenic carcinoma in whom hyponatremia developed as the result of unexplained failure of renal sodium conservation. The data indicate that sustained inappropriate secretion of antidiuretic hormone was probably responsible for the disorder of sodium metabolism. The physiologic abnormality appears to be analogous to that which can be produced by the continuous administration of pitressin® and wa...

1. Addition of antidiuretic hormone (ADH) to the bladders of toads (Bufo marinus) preloaded with (45)Ca causes an increase in the rate of calcium efflux.2. Pretreatment of the serosal surfaces of bladders with phospholipase C prevents the action of ADH on calcium efflux.

A 64-year-old man presented with protracted fever, hyponatremia, and mononeuritis multiplex. Inappropriate antidiuretic hormone secretion was established. The absence of pulmonary infiltrates precluded any lung biopsy. Autopsy revealed malignant angioendotheliomatosis involving multiple organs including the alveolar septa and pulmonary vasculature. An early diagnosis of MAE in the setting of fe...