Introduction Metal complexes play an essential role in agriculture, pharmaceutical and industrial chemistry. Ligand, a metal surrounded by a cluster of ions or molecule, is used for preparation of complex compounds named as Schiff bases, which are condensation products of primary amines and aldehydes or ketones (RCH=NR′, where R & R′ represents alkyl and / or aryl substituents). This paper revi...

Background: Fertility control is an issue of global and national public health concern. Though considerable progress has been made in the development of methods of contraception among females, progress and possibilities are still slow and limited. Therefore, there is a need to develop new contraceptive modalities for males. In this study the antifertility activities of Cornus mas were evaluated...

The microbial transformation of oral contraceptive norethisterone (1) by Cephalosporium aphidicola afforded an oxidized metabolite, 17α-ethynylestradiol (2), while the microbial transformation of 2 by Cunninghamella elegans yielded several metabolites, 19-nor-17α-pregna-1,3,5 (10)trien-20-yne-3,4,17β -triol (3), 19-nor-17α-pregna-1,3,5 (10)-trien-20-yne-3,7α ,17β -triol (4), 19nor-17α-pregna-1,...

A single instillation of an aqueous suspension containing 40 mg. of quinacrine hydrochloride into the uterine horns of adult rats prevented implantation for at least 4 weeks. A suboptimal dose of 5 mg. could be potentiated by the addition of epinephrine or metaraminol. In some animals, the use of the quinacrine hydrochloride suspension resulted in atrophy and necrosis of the treated uterine hor...