We examined sera submitted for autoantibody testing for thyroid microsome antibodies (TMA), elevated thyroid-stimulating hormone (TSH), and free thyroxine concentrations. The frequency of TMA in antinuclear antibody-positive sera was higher (19%) than that in antinuclear antibody-negative sera (12%). Elevated TSH concentrations in serum and subnormal thyroxine concentrations in serum were assoc...

It has been more than 50 years since antinuclear antibodies were first discovered and found to be associated with connective tissue diseases. Since then different methods have been described and used for their detection or confirmation. For many decades immunofluorescent antinuclear antibody test has been the "gold standard" in the diagnosis of these disorders. However to increase the sensitivi...

Background and Purpose The aims of this prospective and multicenter study were to determine the frequency of anticardiolipin and antinuclear antibodies in an unselected ischemic and hemorrhagic stroke population and to evaluate the clinical significance of these autoantibodies. Methods Over a 1-year period, we collected plasma from 481 consecutive patients with ischemic or hemorrhagic stroke at...

Introduction: Adalimumab is a fully human monoclonal anti-TNF-α antibody used in the treatment of rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Other available TNF-α inhibitors, such as infliximab (chimeric monoclonal antibody) and etanercept (soluble anti-TNF-α receptor), can induce the synthesis of autoantibodies and even cause drug-induced lupus. Anti-cyclic citrullin...

The yG-globulin eluted at acid pH from kidney cortex homogenates and isolated glomeruli of five of six patients with lupus nephritis was found to exhibit antinuclear activity, which was not dependent on presence of fresh human serum. Specificity, as demonstrated by absorption of antinuclear activity, was related to nucleoprotein in three glomerular acid eluates and to DNA in two acid eluates as...