OBJECTIVES Once weekly dosing of alendronate has been shown to provide equivalent efficacy to once daily dosing for treatment of osteoporosis in postmenopausal women. Whether patients will prefer weekly dosing to daily dosing for a chronic condition such as osteoporosis has not been studied. The aim of this international study was to assess preference for the weekly or daily dosing regimen of a...

The concept of redevelopment is accompanied by actions and forecasts to improve the quality of the physical-spatial environment inthe cities, that is by the emergence of new facilities and conditions, improving the spatial environment is achieved. This requirement occurs when the coherence, coordination and the performance of the urban area is diminishing and is not responsive to the requiremen...

• Two auditors: one to ask open questions, the other as witness and scribe. • Interview staff individually, establishing their knowledge of trial procedures and incident. Note conflicting information. • Establish key facts: 1. Were participants real and eligible? 2. Did they consent? 3. Are test/clinical measurements/data valid? 4. Was appropriate treatment/intervention given? 5. Was follow-up ...

In 1975, the Education for All Handicapped Children Act (renamed Individuals with Disabilities in 1990) established essential obligation of special education law, which is to develop a student’s individualized program that enables them receive free appropriate public (FAPE). FAPE was defined federal law as and related services that: (a) are provided at expense, (b) meet standards state agency, ...