Background and Objective: BRAF mutations were studied in various populations for prostate carcinoma (PC); however, mutations in BRAF gene are unusual compared to KRAS. Oncogenic activating of BRAF mutations were studied lately in almost 0%-10% of prostate cancer cases. Methods: In this retrospective study, we gathered 100 formalin-fixed ...

We argued in our Flexible Graphplan (FGP) work that the classical definition of the planning problem is too rigid to capture the full subtlety of many real problems. In light of this, we provided a new flexible definition and described a solution strategy based upon the Graphplan framework. Under this definition an action must determine how well its preconditions are met and assert a relative s...

BACKGROUND Generic and condition-specific (CS) oral-health-related quality-of-life (OHRQoL) instruments assess the impacts of general oral conditions and specific oral diseases. Focusing schoolchildren from Arusha and Dar es Salaam, in Tanzania, this study compared the discriminative ability of the generic Child OIDP with respect to dental caries and periodontal problems across the study sites....

purpose: to determine the association between norrie disease (nd) gene mutations and advanced stages of retinopathy of prematurity (rop) in premature neonates who were referred to farabi eye hospital, tehran, iran during 2005-2007. methods: fifty infants including 28 male and 22 female subjects with rop stage 3 or worse were enrolled in this case series. all three exons of nd gene underwent pol...

introduction: mucopolysaccharidosis i (mps-i) is an autosomal recessive lysosomal storage diseases, caused by α-l-iduronidase (idua) enzyme deficiency. the clinical manifestations of mps-i patients are variable ranging from severe to mild, and therefore prediction of disease severity is difficult. from when idua gene has been cloned more than 109 distinct mutations have been identified in it an...

The Arabidopsis short integuments 2-1 (sin2-1) mutant produces ovules with short integuments due to early cessation of cell division in these structures. SIN2 was isolated and encodes a putative GTPase sharing features found in the novel DAR GTPase family. DAR proteins share a signature DAR motif and a unique arrangement of the four conserved GTPase G motifs. We found that DAR GTPases are prese...

One of the disadvantages of using OFDM is the larger peak to averaged power ratio (PAPR) of the time domain signal as compared with the conventional single carrier transmission method. The OFDM signal with larger PAPR will cause the undesirable spectrum regrowth and the larger degradation of bit error rate (BER) performance both due to the inter-modulation products occurring in the non-linear a...

In Escherichia coli, the replication origin oriC consists of two functional regions: the duplex unwinding element (DUE) and its flanking DnaA-assembly region (DAR). ATP-DnaA molecules multimerize on DAR, unwinding DUE for DnaB helicase loading. However, DUE-unwinding mechanisms and functional structures in DnaA-oriC complexes supporting those remain unclear. Here, using various in vitro reconst...

We revisit the idea of road-wheel pairs, first introduced 50 years ago by Gerson Robison and later popularized by Stan Wagon and his square-wheeled tricycle. We show how to generate such pairs geometrically: the road as a roulette curve and the wheel as a pedal curve. Along the way we gain geometric insight into two theorems proved by Jakob Steiner relating the area and arc length of a roulette...