Sepideh shakeri
Cancer Molecular Pathology Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
[ 1 ] - The Association of Gastritis and Peptic Ulcer With Polymorphisms in the Inflammatory-related Genes IL-4 and IL-10 in Iranian Population
Background and Objective: The current study aimed at assessing the relationship between gastritis and peptic ulcer susceptibility and inflammation-related gene polymorphisms in Iranian patients. Gastritis and peptic ulcer are common medical complications with serious outcomes on the quality of life. Inflammatory responses of gastric mucosa are associated with helicobac...
[ 2 ] - KRAS Codon 12 and 13 Mutations in Gastric Cancer in the Northeast Iran
Background & objective: KRAS mutations are reported in many types of cancers including pancreas, lung, colon, breast, and gastric (GC). High frequency of KRAS mutation is observed in the pancreas, colon, and lung cancers; they commonly arise in codon 12 and 13 of exon 2. Due to the lack of information about the frequency of KRAS</...
[ 3 ] - Chromogenic in situ Hybridization Compared with Real Time Quantitative Polymerase Chain Reaction to Evaluate HER2/neu Status in Breast Cancer
Background and objective: The assessment of human epidermal growth factor receptor 2 (HER2) status has become of great importance in the diagnosis of breast cancer. The aim of this study was to investigate the diagnostic value of quantitative Polymerase Chain Reaction (qPCR) and Chromogenic In Situ Hybridization (CISH) to assess HER2 status of biopsy specimens. <...
[ 4 ] - بررسی شیوع عفونت سایتومگالو ویروس در دریافت کنندگان کلیه یکسال پس از پیوند
مقدمه: علی رغم پیشرفت های چشمگیر سال های اخیر در حوزه درمان، مشکل عفونت های ویروسی هنوز هم با چالش جدی رو به رو است. عفونت سایتومگالو ویروس یکی از دلایل مهم مرگ و میر در بیماران پس از عمل پیوند کلیه می باشد. هدف از این مطالعه بررسی شیوع و عوامل خطرساز ابتلا به عفونت سایتومگالو ویروس در این بیماران پس از پیوند در شهر مشهد در شمال شرقی ایران می باشد. مواد و روش ها: ما در یک مطالعه گذشته نگر، پرو...
[ 5 ] - Prevalence of MPL (W515K/L) Mutations in Patients with Negative-JAK2 (V617F) Myeloproliferative Neoplasm in North-East of Iran
Background and Objective: Janus kinase 2 (JAK2) and Myeloproliferative Leukemia (MPL) mutations are confirmatory indicators for Myeloproliferative Neoplasm (MPN). The current study was performed to determine the frequency of MPL mutation in MPN patients without JAK2 mutation, in order to assign MPL mutation frequency in North-East of Iran.Methods: Total o...
[ 6 ] - Molecular Status of BRAF Mutation in Prostate Adenocarcinoma: The Analysis of 100 Cases in North-East of IRAN
Background and Objective: BRAF mutations were studied in various populations for prostate carcinoma (PC); however, mutations in BRAF gene are unusual compared to KRAS. Oncogenic activating of BRAF mutations were studied lately in almost 0%-10% of prostate cancer cases. Methods: In this retrospective study, we gathered 100 formalin-fixed ...
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