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عباس شیردل

دانشیار گروه داخلی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

[ 1 ] - بررسی کمبود کوبالامین و اسید فولیک در سالمندان شهر مشهد با تعیین نقطه برش توسط شاخص های آزمایشگاهی

مقدمه   کمبود کوبالامین و فولات در سالمندان شایع است. معرفی یک نقطه برش برای تخمین کمبود کوبالامین و فولات در حدود پایین و بینابینی قبل از بروز علایمآنمی، عصبی ادراکی و روانی در سالمندان ضروری به نظرمی رسد.   روش کار   در این مطالعه تحلیلی- توصیفی در سال 1385،280 سالمند بالای 65 سال از مناطق 12 گانه شهر مشهد در بیمارستان امام رضا (ع) پذیرش شدند. توسط پزشک عمو می معاینات فیزیکی به عمل آمد وسایر ...

[ 2 ] - معرفی یک مورد نوروآکانتوسیتوز

مقدمه: نوروآکانتوسیتوز یک اختلال نادر نورودژنراتیو است که معمولاً وراثت اتوزومال مغلوب دارد. این سندرم بااختلالات حرکتی مختلف مثل تیک، دیستونی دهانی، گازگرفتن لب و زبان و فقدان رفلکسهای تاندونی همراهی دارد. تغییرات رفتاری و شناختی در آن به کرات دیده می شود. آکانتوسیتوز گلبولهای قرمز همراه با لیپوپروتئینهای طبیعی سرم مشخصه آن می باشد. در این مقاله یک مورد نورو آکانتویستوز معرفی شده است. معرفی بیم...

[ 3 ] - Homocysteine, Cobalamin and Folate Status and their Relations to Neurocognitive and Psychological Markers in Elderly in Northeastern of Iran

      Objective(s): Incidence of neurocognitive and psychological disorders may be related to serum homocystein (Hcy), cobalamin (vitamin B12 ) and folate levels in old people. The aim of this study was to assess the relation between Hcy, cobalamin, folate and neurocognitive and/or psychological disorders in the elderly.   Materials and Methods: In this cross-sectional study, 280 subjects with ...

[ 4 ] - Human T Lymphotropic Virus Type I (HTLV-I) Oncogenesis: Molecular Aspects of Virus and Host Interactions in Pathogenesis of Adult T cell Leukemia/Lymphoma (ATL)

    The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insufficient for establishment of transformed cells that develop cancer in only ...

[ 8 ] - Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad)

  The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear to be involved as risk factors for developing HAM/TSP. We investigated the possible contribution of interleukin-10 (IL-10) as a risk factor to HA...

[ 10 ] - A Functional Polymorphism of the Granulocyte Macrophage Colony Stimulating Factor is not Associated with the Outcome of HTLV-I Infection

Introduction Genetic background has known to be associated with the outcome of human T cell lymphotropic virus (HTLV) type I infection. In The present study we investigate the association between GM-CSF gene polymorphisms with the outcome of HTLV-I infection. Materials and Methods We analyzed 3 single-nucleotide polymorphisms in the promter region of granulocyte macrophage colony stimulating...

[ 11 ] - Absence of FLT3 mutations in Iranian adult T-cell leukemia/lymphoma patients

Background: Adult T cell leukemia lymphoma (ATLL) is a rare disease, significantly linked to the infection by the human T-cell lymphotropic virus 1(HTLV-1). ATLL is typically preceded by decades of clinical latency during which infected cells accumulate selectable traits leading to a malignant transformation. Amongst all the HTLV-1 infected carriers only about 3-5% will develop ATLL. Despite th...

[ 12 ] - BCR-ABL fusion genes and laboratory findings in patients with chronic myeloid leukemia in northeast Iran

Background: A specific chromosomal abnormality, the Philadelphia chromosome (BCR-ABL fusion), is present in all patients with chronic myeloid leukemia (CML). The b2a2 and b3a2 fusion mRNAs encode p210 fusion protein p210 and e1a2 encode p190. The aim of this study was to evaluate the frequency of BCR-ABL fusion transcript variants in Northeast of Iranian CML patients and to compare the laborato...

[ 13 ] - Interaction of perforin and granzyme B and HTLV-1 viral factors is associated with ATL development

Objective(s): Human T cell leukaemia virus type 1 (HTLV-1) is associated with adult T cell leukaemia (ATL), a malignant lymphoproliferative disease that infects CD4 T cells. It is not clear why the majority of HTLV-1-infected individuals remain asymptomatic carries (ACs) and a minority develop ATL. Cellular immune response has a critical role in ATL and destroys malign...