DMB (Dimethylbarbituric) and DETB (Diethylthiobarbituric) are both barbituric thiobarbituric acid derivatives respectively, that forms enamines with the Nα amine of amino acids. These compounds were found to be stable crystalline solids show stability in standard acidic basic conditions used for solid-phase peptide synthesis (SPPS) strategies. protecting groups cleaved by a mild solution 2 % hy...

The retention time of 22 barbituric acid derivatives was measured on a narrow-bore porous graphitized carbon (PGC) column using water-dioxane mixtures as mobile phases. The capacity factor (k), theoretical plate number (N), and asymmetry factor (AF) were calculated for each solute in each mobile phase. The relationships between chromatographic characteristics and physicochemical parameters of s...

This review presents a survey of the condensations of 3-formylchromone with various active methylene and methyl compounds, e.g. malonic or barbituric acid derivatives, five-membered heterocycles, etc. The utilisation of the condensation products for the synthesis of different heterocyclic systems, which is based on the ability of the gamma-pyrone ring to be opened by the nucleophilic attack is ...

By R. J. CALVERT, E. HUnwoilTil AND A. L. MACBEAN I HE OCCASIONAL DEVELOPMENT of megaloblastic anemia during the administration for months or years of certain anticonvubsant drumgs ( phenytom sodium and/or primidone, with or withoumt phenobarbital ) has been reviewed by Gydell#{176} and Newman and Sumner.11 Ouir report concerns an epileptic patient who presented as a gynecologic emergency with ...