Article type: Original article Objective(s): FOXP3 gene is an X-linked gene that encodes FOXP3 protein, an essential transcription factor in CD4+CD25+FOXP3+ regulatory T (Treg) cells. We aimed, in the present study, to investigate the association of two FOXP3 polymorphisms, -2383 C/T (rs3761549) and IVS9+459 T/C (rs2280883), with lung cancer. Materials and Methods: In a case-control study we an...

Article type: Original article Objective(s): The present study was undertaken to determine the effects of acute exposure to malathion on oxidative stress and cytotoxic potential of anticholinesterase insecticide, malathion in reproductive toxicology of adolescent male mice. Materials and Methods: Thirty two adolescent male mice at pubertal age were treated with 500 mg/kg body weight (BW) of mal...

It has become axiomatic that basic science faculty and research programs at medical schools must support themselves. The days when excess clinical revenue was used to support basic research are long gone. With the pressure of managed care and faculty practice programs on medical school budgets, it appears that medical school leaders are looking everywhere but at clinical programs for critical s...

Meet @ERStalk Assembly 3: Basic and Translational Sciences http://ow.ly/66E830hFi7U.

Article type: Original article Objective(s): To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. Materials and Methods: Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). MCAO/R model was established by Longa’s method, and reperfusion was allowe...

Article type: Original article Objective(s): Echis carinatus is one of the venomous snakes in Iran. The venom of Iranian Echis carinatus is a rich source of protein with various factors affecting the plasma protein and blood coagulation factor. Some of these proteins exhibit types of enzymatic activities. However, other items are proteins with no enzymatic activity. Materials and Methods: In or...

Resident-as-teacher courses are pretty common in Western medical schools however they are a rarity in Asian and developing countries. The current report is a scholarly analysis of a three day orientation program for senior residents in order to improve their functioning by providing new template either for supplementing basic workshops for faculty or to advocate a change in system. The experien...

This paper describes a new undergraduate course that serves two purposes. First, it satisfies a general education requirement in mathematical sciences, and second, it serves as one of four possible first courses for computer science majors. The course has no prerequisites: the student population is drawn primarily from college freshmen. This paper focuses on the curriculum, which blends topics ...