Genome-wide association studies (GWASs) have primarily focused on the association between individual genetic markers and risk of disease. We applied a novel approach that integrates skin expression-related single-nucleotide polymorphisms (eSNPs) and pathway analysis for GWAS of basal cell carcinoma (BCC) to identify potential novel biological pathways. We evaluated the associations between 70,9...

INTRODUCTION Non-melanoma skin cancer (NMSC) is the most common malignancy in the United States, with more than 5.4 million cases diagnosed annually.1 NMSC is categorized as either basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), with BCC occurring at a fourfold to fi vefold higher rate than SCC. Standard fi rst-line treatment of BCC usually involves local procedures, such as curett...

The existence and stability under pressure of three phases of vanadium are calculated from first principles. The phases are one body-centered cubic (bcc) and two rhombohedral phases (rh(u) and rh(l)), which have greater and lower α values than the primitive bcc rhombohedral cell. The bcc phase is shown in two ways to become unstable at 0.65 Mbar, in agreement with an observed phase transition, ...

The following conclusions are derived from an epidemiological study. Reduced repair of ultraviolet (UV)-induced DNA damage contributes directly to basal cell carcinoma (BCC) in individuals with prior sunlight overexposure. A family history of BCC is a predictor of low DNA repair. Repair of UV-damaged DNA declines at a fixed rate of approximately 1% per annum in noncancerous controls. The DNA re...

In India, there are no precise reports of the prevalence of Burkholderia cepacia complex (BCC) infections due to the lack of awareness and difficulty in identification by routine clinical laboratories. In most cases, BCC has been ambiguously reported as nonfermentative Gram-negative bacilli (NFGNB) or simply Pseudomonas spp.1,2. For this reason, reports of disease due to BCC are rare and BCC ha...

Both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are very common in skin malignancy. Operative therapy is the first choice at the treatment for SCC and BCC in early stage. After excision for large skin tumor, occasionally we use skin flap or musculocutaneous flap or free flap. At the old patient of Stage III and IV SCC and BCC, sometimes reduction surgery is useful at the combi...

Tumor-associated macrophages (TAMs) and cyclooxygenase-2 (COX-2) are associated with invasion, angiogenesis, and poor prognosis in many human cancers. However, the role of TAMs in human basal cell carcinoma (BCC) remains elusive. We found that the number of TAMs infiltrating the tumor is correlated with the depth of invasion, microvessel density, and COX-2 expression in human BCC cells. TAMs al...

A simple cluster model calculation scheme which successfully describes the line shape and intensity ratio of recent spin resolved Fe 3s spectra of metallic Fe has been developed. From fitting the 3s spectra of bcc-bulk Fe, we found that the configuration interaction effect is important to the understanding of the 3s spectra. This model was applied to the Fe 3s spectra obtained from the ultrathi...

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Validation studies of crystal plasticity fi nite element models typically compare model predictions of strain fi elds withexperimental measurements; often ignored are the grain rotations predicted by the model. Accurate predictions ofcrystallographic rotations are necessary for trustworthy predictions of strain fi elds, deformed texture, and failure.This is especially important ...