BACKGROUND In psychiatric inpatients, administration of pro re nata benzodiazepines is a common practice. Benzodiazepine use is associated with potential complications of risk of abuse, cognitive impairment, and falls. An interest in accreditation is growing rapidly among many countries to enhance the quality of health care services. We aimed to investigate whether hospital accreditation drives...

BACKGROUND Benzodiazepines are often prescribed long-term inappropriately. We aimed to systematically review and meta-synthesise qualitative studies exploring clinicians' experiences and perceptions of benzodiazepine prescribing to build an explanatory model of processes underlying current prescribing practices. METHODS We searched seven electronic databases for qualitative studies in Western...

A series of sulfamide and triazole benzodiazepines were obtained with the principle of bioisosterism. The p53-murine double minute 2 (MDM2) inhibitory activity and in vitro antitumor activity were evaluated. Most of the novel benzodiazepines exhibited moderate protein binding inhibitory activity. Particularly, triazole benzodiazepines showed good inhibitory activity and antitumor potency. Compo...

In this study, we analyzed patterns of combined benzodiazepines and alcohol use among the Spanish general population over the age of 16 years. The study was based on information from the 1997 Spanish National Household Health Survey. A total of 6,396 persons over 16 years of age, a representative sample of noninstitutionalized Spaniards, were surveyed. One percent of the population are consumer...

Benzodiazepines (BZDs) are an important class of psychoactive drugs with hypnotic-sedative, myorelaxant, anxiolytic and anticonvulsant properties due to interaction the GABAa receptor in central nervous system mammals. BZDs interesting both clinical forensic toxicology for their pharmacological characteristics potential abuse. The presence a non-planar diazepine ring generates chiral conformati...

Cohen: Early reports suggested that benzodiazepines, specifically diazepam, were associated with higher risk of cleft lip and/or cleft palate in children exposed during the first trimester, but several subsequent reports did not replicate that finding. Over the next decade or so, a number of investigators studied effects of individual benzodiazepines and benzodiazepines as a class, but the meth...

BACKGROUND Previous studies from North America, Europe and Australia have reported high levels of benzodiazepine use among opiate-dependent patients in opiate maintenance treatment. However, to date, there are no available data on patterns of abuse and dependence on benzodiazepines according to DSM criteria among these patients. AIMS To describe the independent correlates of use, abuse and de...

background: for treatment of severe alcohol withdrawal syndrome, high dose benzodiazepines (bzds) may cause delirium and over-sedation. phenobarbital (pbt) is a long-acting barbiturate effective for the treatment of alcohol withdrawal. given the potential benefits of pbt, we sought to investigate the effectiveness of pbt as adjunctive treatment for alcohol withdrawal. methods: this was a retros...

Benzodiazepines are primarily used for the treatment of generalized anxiety disorder, insomnia and status epilepticus. These drugs can also be useful in hyperaroused states, catatonic stupor, manic episodes, and akathisia. This paper will review indications for their use in various psychotic conditions.