Sepsis is a leading cause of death that is characterized by uncontrolled inflammatory response. In this study, we report that scavenger receptor BI (SR-BI), a high density lipoprotein receptor, is a critical survival factor of sepsis. We induced sepsis using an established septic animal model, cecal ligation and puncture (CLP). CLP induced 100% fatality in SR-BI-null mice but only 21% fatality ...

In children, behavioral inhibition (BI) in response to potential threat predicts the development of anxiety and affective disorders, and primate lesion studies suggest involvement of the orbitofrontal cortex (OFC) in mediating BI. Lesion studies are essential for establishing causality in brain-behavior relationships, but should be interpreted cautiously because the impact of a discrete lesion ...

Cigarette smoke-induced emphysema is thought to involve reduction of antielastolytic capacity, resulting in elevated elastase activity and lung tissue damage. Peripheral lavage collected from ten asymptomatic subjects immediately before and 20 min after smoking two high tar cigarettes was analysed for neutrophil elastase (NE) inhibitory capacity (IC), alpha 1-proteinase inhibitor (PI) function,...

A constant time and space algorithm for embedding the hypercube architecture into the 3-dimension mesh (3Dmesh) is presented. This enables the cubei operation to be performed on the embedded hypercube machine where the interprocessor communication function cubei is defined on the embedded hypercube's PEs as cubei (bn−1LbiLb0 ) = bn−1LbiLb0 and bi is the binary complement of bi .

The electron spin resonance (ESR) and magnetization (M) studies of Bi-manganites were undertaken to understand the coexistence of various magnetic phases and their effect on charge ordering as a function of composition and temperature. The studies on several compositions of Bi-manganites reveal that the electronic phase separation (PS) is an in‐ trinsic phenomenon in this system.

We construct an invariant of the bi-Lipschitz equivalence of analytic function germs (Rn,0) → (R,0) that varies continuously in many analytic families. This shows that the bi-Lipschitz equivalence of analytic function germs admit continuous moduli. For a germ f the invariant is given in terms of the leading coefficients of the asymptotic expansions of f along the sets where the size of |x||grad...

We propose to model breast tissue in mammograms covering both density and tissue patterns. The breast tissue density modelling is based on the global density distribution of the breast region. We segment the whole breast region into a number of uniform density sub-regions and construct an overall density model of the breast using the relative proportions of these sub-regions. The breast tissue ...

The electrical conductance of epitaxial Bi thin films grown on BaF(2)(111) by molecular beam epitaxy has been systematically investigated as a function of both film thickness (4-540 nm) and temperature (5-300 K). Unlike bulk Bi as a prototypical semimetal, the Bi thin films up to 90 nm are found to be insulating in the interior but metallic on the surface. This finding not only has unambiguousl...

In children, behavioral inhibition (BI) in response to potential threat predicts the development of anxiety and affective disorders, and primate lesion studies suggest involvement of the orbitofrontal cortex (OFC) in mediating BI. Lesion studies are essential for establishing causality in brain– behavior relationships, but should be interpreted cautiously because the impact of a discrete lesion...