Background Accurate and practical outcome measures for clinical trials in systemic lupus erythematosus (SLE) are lacking. The SLE Disease Activity Score (SLE-DAS) is a recently validated 17-item instrument, with high accuracy sensitivity to changes disease activity. SLE-DAS definitions of remission low activity (LDA) were newly the setting 1,2 . These may constitute accurate easy apply endpoint...

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let g be a connected simple (molecular) graph. the distance d(u, v) between two vertices u and v of g is equal to the length of a shortest path that connects u and v. in this paper we compute some distance based topological indices of h-phenylenic nanotorus. at first we obtain an exactformula for the wiener index. as application we calculate the schultz index and modified schultz index of this ...

Background ABBV-599 is a novel combination of upadacitinib (UPA), reversible JAK inhibitor approved for the treatment several autoimmune diseases, and elsubrutinib (ELS), covalent BTK being developed immune-mediated inflammatory diseases. The efficacy safety profile monotherapies (UPA ELS) (ABBV-599) were evaluated in systemic lupus erythematous (SLE) global Phase 2 Study SLEek (NCT#03978520). ...

background: doppler indices of umbilical artery are used as indicator of fetal well being. objective: to compare doppler parameters of umbilical artery including pulsatility index (pi) and resistance index (ri) in patients with preeclampsia with those of normal pregnancies and to evaluate the diagnostic characteristics of these parameters in preeclampsia. materials and methods: in a case contro...

let $g$ be a connected graph, and let $d[g]$ denote the double graph of $g$. in this paper, we first derive closed-form formulas for different distance based topological indices for $d[g]$ in terms of that of $g$. finally, as illustration examples, for several special kind of graphs, such as, the complete graph, the path, the cycle, etc., the explicit formulas for some distance based topologica...

drought as a natural but temporary imbalance of water availability is the interaction between natural environment and human life resulting in diminished water resources availability and reduced carrying capacity of the ecosystems. drought indices are essential elements for an efficient drought monitoring system. these indices make the transforming information of climatic anomalies easier and al...

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