Probiotics are usually defined as products which contain viable non-pathogenic micro-organisms able to confer health benefits to the host. There are specific gastrointestinal effects of probiotics such as alleviating inflammatory bowel disease, reducing acute diarrhoea in children, inhibiting Salmonella and Helicobacter pylori, removing cholesterol, secreting enzymes and bacteriocins and immuno...

Manufacturing Quality and Control........................................................ 3 Ensuring Quality of Source Pancreata.................................................. 3 Manufacturing of Islets ....................................................................... 3 Assessing the Final Product ................................................................ 4 Islet Comparability ......

Artificial Development is a promising approach to evolutionary design optimization inspired by biological development. However, there is still no consensus as to which problem classes this approach has a clear advantage over classical direct encodings. We attack this problem by introducing the concept of fitness function modifiers based on complexity. Our results indicate that using these modif...

-Glucans belong to a group of biologically active natural compounds called biological response modifiers. These substances represent highly conserved structural components of cell walls in yeast, fungi, grain and seaweed. The effects of -glucan on immune reactions are well established however direct comparisons of the biological activities of several individual glucans are extremely rare. As th...

Cancer immunoprevention refers to the modulation of the host immune response to control the initiation or development of cancer. The significant role of host immunity in early tumorigenesis has only recently been confirmed, as a better understanding of the mechanisms, molecules and cells involved in tumor immunology have been elucidated over the past two decades. Of utmost importance, preclinic...

INTRODUCTION Hospital-acquired pneumonia after surgery is one of the major causes of septic shock. The excessive inflammatory response appears to be responsible for the increased susceptibility to infections and subsequent sepsis. The primary aim of this study was to investigate immune parameters at the onset of pneumonia, before the development of subsequent septic shock. The secondary aim was...

The liver possesses distinct tolerogenic properties because of continuous exposure to bacterial constituents and nonpathogenic food antigen. The central immune mediators required for the generation of effective immune responses in the liver environment have not been fully elucidated. In this report, we demonstrate that the liver can indeed support effector CD8(+) T cells during adenovirus infec...