Biological response modifiers (BRMs) of current clinical interest may be divided into two categories: immunomodulating agents and colony stimulating factors (CSFs). The first are employed to potentiate the host defences towards the tumor but results have proved disappointing in non-small cell lung cancer (NSCLC). With regard to the second, the real dose increment which may be ascribed to CSFs i...

We argue that the superlative modifiers at least and at most quantify over a scale of answers to the current question under discussion (and in this sense, resolve issues), and that they draw attention to the individual possibilities along the scale (and in this sense, raise issues for discussion). The point of departure is a simple analysis on which at least denotes what only presupposes, and a...

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The superlative modifiers at least and at most are quite famous, but their cousins at best, at the latest, at the highest, etc., are less well-known. This paper is devoted to the entire family. New data is presented illustrating the productivity of the pattern, identifying a generalization delimiting it, and showing that the cousins, too, have the pragmatic effects that have attracted so much a...

Our long-term goal is to contribute to the integration of formal and lexical semantics. Our more immediate theoretical starting point is the idea of “text as theory”, within a model-theoretic semantic framework. We describe a set of empirical problems in the domain of genitive modifiers which offer a challenge to theories of the integration of lexical, compositional, and contextual information....

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