introduction in order to treat uveal melanoma , first, radioactive seeds are laid on a silicone- made substance which is called silastic after that they are inserted in the plaque, and finally, this plaque containing silicone-made substance is stitched to the sclera surface. the dose gradient within the tumor and healthy tissues can be varied due to changing the silastic thickness between scler...

Purpose: To update the accommodation mechanisms and propose a dual-wavelength, dual-function laser system for presbyopia glaucoma treatments.
 Study Design: Laser sclera softening (LSS) increased of presbyopic eyes.
 Place Duration Study: New Taipei City, Taiwan, between Jan., 2023 Feb., 2023.
 Methodology: Accommodation gain (AG) can be improved by: (i) thermal shrinkage scleral...

With this investigation, the anatomy of bulbus oculi was studied in 12 Akkaraman sheep. The oculi’s specific morphological features breed were introduced study. In border cornea and scle-ra, limbus ended at point where it entered under sclera. eyes examined, existence rima cornealis sclera not observed. Based on observations made, center thinner com-parison with its periphery. sheep, determined...

PURPOSE One of the current limitations in developing novel glaucoma drugs that target the trabecular meshwork (TM) is the induced corneal toxicity from eyedrop formulations. To avoid the corneal toxicity, an alternative approach would be to deliver TM drugs through the sclera. To this end, we quantified ex vivo diffusion coefficient of a potential TM drug, ethacrynic acid (ECA), and investigate...

PURPOSE The proteoglycans synthesized and accumulated within the adult human sclera (aged 50 to 80 years) were identified by their size, glycosaminoglycan side chains, and core proteins in an effort to characterize the proteoglycan content of the human sclera. METHODS Sclerae, unlabeled, or radiolabeled in organ culture with 35SO4 or 3H-proline, were extracted in 4M guanidine-HCl and separate...

PURPOSE It is proposed that the sclera is a metabolically active and pharmacologically responsive tissue. These studies were undertaken to determine whether prostaglandin exposure can enhance scleral permeability to high-molecular-weight substances. METHODS Topical prostaglandin F2 alpha (PGF2 alpha) was administered to monkeys to determine if this altered the amount of scleral matrix metallo...

A 16 yr old female presented with generalized weakness and easy fatigability since 2 months. Her medical history included that she had sickle cell disease (ss pattern) on regular treatment. She denied smoking and consumption of alcohol. She had adequate calcium intake and her menstrual history was non-contributory. History of right tibial diaphysial fracture 1 year back followed by refracture a...

AIM To identify and understand the relationship between co-expression pattern and clinic traits in uveal melanoma, weighted gene co-expression network analysis (WGCNA) is applied to investigate the gene expression levels and patient clinic features. Uveal melanoma is the most common primary eye tumor in adults. Although many studies have identified some important genes and pathways that were re...

The histopathology of the posterior half of one eye and the optic nerves of a man with Hunter's syndrome, who was known to have disc oedema without raised intracranial pressure for 11 years of his life, is reported. The possible pathogenesis of the disc oedema is discussed; an important contributory factor was the deposition of abnormal mucopolysaccharides within the sclera. This caused gross t...

The suprachoroidal space (SCS), a potential between the sclera and choroid, is becoming an applicable method to deliver therapeutics back of eye. In recent years, vast amount research in field has been carried out, with new discoveries different areas interest, such as imaging, drug delivery methods, pharmacokinetics, pharmacotherapies preclinical clinical trials advanced therapies. SCS can be ...