We are developing a new, animal-free assay for determination of the sensitizing potential of a substance. The design of this assay is based on current immunological knowledge of the pathogenesis of allergic contact dermatitis. It integrates human dendritic cells and keratinocytes, which are both known to be critically involved in vivo. The read-out system uses molecular responses typically occu...

Abstract Purpose and context This paper aims to establish principles for the increased application use of life cycle sustainability assessment (LCSA). Sustainable development (SD) encompassing resilient economies social stability global system is growingly important decision-makers from business governments. The “17 SDGs” emerge as a high-level shared blueprint peace, abundance, prosperity peop...

The main objective of the present study was to prioritize the allocation of water resources of Chahnimeh reservoirs from economic, social, and environmental perspectives in 2015-2016 season using fuzzy analytic hierarchy process (FAHP) and fuzzy technique for order preference by similarity of an ideal solution (FTOPSIS) as the branches of fuzzy multiple-criteria decision-making (MCDM) models. D...

This paper introduces a research framework to identify barriers from a remanufacturing supply chain perspective including strategic (governmental) and operational dimensions. Using responses from expert practitioners in a truck engine remanufacturer in China, a grey-based Decision-Making Trial and Evaluation Laboratory (DEMATEL) method is applied to examine the cause-effect relationships among ...

Performance analysis is an important way for hospitals to achieve higher efficiency and effectiveness in providing services to their customers. The performance of the healthcare system can be measured by many indicators, but it is difficult to improve them simultaneously due to the limited resources. A feasible way is to identify the central and influential indicators to improve healthcare perf...