Interest in brain stimulation therapies has been rejuvenated over the last decade and brain stimulation therapy has become an alternative treatment for many neurological and psychiatric disorders, including Parkinson's disease (PD), dystonia, pain, epilepsy, depression, and schizophrenia. The effects of brain stimulation on PD are well described, and this treatment has been widely used for such...

BackgroundHigh frequency (130 Hz) subthalamic Deep-Brain-Stimulation (STN-DBS) optimally improves cardinal motor symptoms in Parkinson disease (PD). Low stimulation frequencies (60–80 improve axial some patients and, according to preliminary evidences, may also have a beneficial effect on the cognitive component of planning.ObjectiveTo analyze configuration P300 cortical event-related auditory ...

Abstract Deep brain stimulation (DBS) is a promising neuromodulation therapy, but the neurophysiological mechanisms of DBS remain unclear. We performed high-speed membrane voltage fluorescence imaging individual hippocampal CA1 neurons during delivered at 40Hz or 140Hz, free electrical interference, in awake mice. discovered that reliably depolarizes somatic potentials without suppressing spike...

abstract introduction: it is demonstrated that the degree of clinical improvement in parkinson's disease (pd) achieved by deep brain stimulation (dbs) is largely dependent on the accuracy of lead placement. in addition, individual variability in the situation of subthalamic nucleus (stn) is responsible for spatial inter-individual fluctuations of the real patient's target. objective: our study ...

BACKGROUND Deep brain stimulation (DBS) for the treatment of neurologic diseases has markedly increased in popularity over the past 15 years. This review primarily focuses on movement disorder applications and efficacy of DBS, but also briefly reviews other promising new and old uses of DBS. REVIEW SUMMARY A multidisciplinary team consisting of a movement disorders neurologist, a functional n...

11 Abstract. Noninvasive brain stimulation (NIBS) techniques such as transcranial 12 magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have 13 recently attracted interest due to their potential for transiently improving cognitive 14 functions and memory in human beings. In aging, these techniques may prove 15 particularly valuable given the impact of age-related cogn...

Migraine is a very prevalent disease with great individual disability and socioeconomic burden. Despite intensive research effort in recent years, the etiopathogenesis of the disease remains to be elucidated. Recently, much importance has been given to mechanisms underlying the cortical excitability that has been suggested to be dysfunctional in migraine. In recent years, noninvasive brain stim...