BACKGROUND AND PURPOSE Although it is well established that brain maturation correlates temporally with the functions the newborn or infant performs at various stages of development, the precise relationship between function and anatomic brain maturation remains unclear. The purpose of this study was to investigate the developmental changes of regional cerebral blood flow (rCBF) in infants and ...

PURPOSE The aim of this multi-center study was to assess the diagnostic capability of visual assessment in L-methyl-11C-methionine positron emission tomography (MET-PET) for differentiating a recurrent brain tumor from radiation-induced necrosis after radiotherapy, and to compare it to the accuracy of quantitative analysis. METHODS A total of 73 brain lesions (glioma: 31, brain metastasis: 42...

increased metabolic activity in muscle secondary to excessive muscle activity during the uptake phase and shortly before fdg injection is a known phenomenon. we present fdg pet/ct findings in a young male, known case of carcinoma maxilla his scan showed diffuse increased metabolic activity in multiple skeletal muscle groups. there was history of unaccustomed, strenuous sports activity of skiing...

Introduction: The key characteristics of positron emission tomography (PET) are its quantitative capability and its sensitivity, which allow the in vivo imaging of biochemical interactions with small amounts of tracer concentrations. Therefore, accurate quantification is important. However, it can be sensitive to several physical factors. The aim of this investigation is the assessment of the e...

In the present study we examined the effects of prenatal manganese (Mn) intoxication on [ H]glucose uptake in the brain of rats lesioned as neonates with 6-hydroxydopamine (6-OHDA). MnCl • 4H O (10,000 ppm) was added to the drinking water of pregnant Wistar rats for the duration of pregnancy. On the day of parturition, Mn was discontinued as an additive to the drinking water. The control group ...

In the present study we examined the effects of prenatal manganese (Mn) intoxication on [(3)H]glucose uptake in the brain of rats lesioned as neonates with 6-hydroxydopamine (6-OHDA). MnCl(2) . 4H(2)O (10,000 ppm) was added to the drinking water of pregnant Wistar rats for the duration of pregnancy. On the day of parturition, Mn was discontinued as an additive to the drinking water. The control...

During exercise regional cerebral blood flow (rCBF), as blood velocity in major cerebral arteries and also blood flow in the internal carotid artery increase, suggesting an increase in blood flow to a large part of the brain. Such an increase in CBF is independent of the concomitant increase in blood pressure but is modified by the alteration in arterial carbon dioxide tension (PaCO(2)). Also, ...

UNLABELLED We recently demonstrated that (11)C-MePPEP, a PET ligand for CB(1) receptors, has such high uptake in the human brain that it can be imaged for 210 min and that receptor density can be quantified as distribution volume (V(T)) using the gold standard of compartmental modeling. However, (11)C-MePPEP had relatively poor retest and intersubject variabilities, which were likely caused by ...

Tritiated leucine was intraperitoneally injected into normal and castrated female rats, and the uptake in the brain was autoradiographically studied 2hr after the injection. Radioactivity was estimated by counting the number of reduced grains in various areas of the brain. In normal animals, the highest uptake of radioisotope was found in the cell bodies of neurons in the supraoptic nucleus. A ...

Silver Nanoparticles (AgNPs) have gained considerable interests during the last decade due to their excellent antimicrobial activities. Despite their extensive use, the potential toxicity of these nanoparticles and possible mechanisms by which they may induce adverse reactions have not received sufficient attention and no specific biomarker exist to describe and quantify their toxic effects. Na...