Mussel-inspired coatings, known for their outstanding substrate-independent adhesive capabilities, have numerous potential applications in materials science and biomedical fields. To improve the understanding of how these polymers’ molecular structure chemical composition affect coating mechanisms resulting properties, herein three mussel-inspired polymers are developed: dendritic polyglycerol ...

Catechols are components of many metal-chelating compounds, including siderophores that are naturally occurring iron(III) chelators excreted by microorganisms. Catechol derivatives are poorly soluble in organic media and the synthesis of catechol-containing molecules requires the use of protected catechol precursors with improved organic solubility. We therefore developed 2,2-diphenyl-benzo[1,3...

Oxidative stress, including the reactive oxygen or nitrogen species generated in the enzymatical oxidationor auto-oxidation of an excess amount of dopamine, is thought to play an important role in dopaminergic neurotoxicity. Dopamine and its metabolites containing 2 hydroxyl residues exert cytotoxicityin dopaminergic neuronal cells, primarily due to the generation of highly reactive dopamine an...

The importance of 0-methylation of catecholamines and other catechols as a metabolic pathway has been amply shown (l-4). The isolation of “Substanz Y,” a p-O-methylcatechol derivative from beef adrenal glands (5), and the occurrence of p-o-methylcatechol derivatives in urine (6) are suggestive of p-o-methylation in viva. Previous studies (7) have shown that in vitro the enzyme 0-methyltransfera...