Since 1983, Slovenia has been offering well-established, successful, and fully reimbursed IVF programme to infertile couples. On the grounds of data gathered at the Slovenian IVF units we aimed to determine whether the fully accessible IVF treatment system can provide notable success considering cumulative delivery rate (cDR). Longitudinal analysis of getting cDR was performed in 810 IVF cycles...

The aim of this study is to compare the incidence of postoperative dysphagia/dysphonia between anterior cervical discectomy and fusion (ACDF) with an anterior plate and cervical disc replacement (CDR). PubMed, EMBASE, Web of science, Ovid, Cochrane library and China Knowledge Resource Integrated Database (until March 1, 2016) were searched. RCTs that reported the number of patients who suffered...

5-Aza-2'-deoxycytidine (5-Aza-CdR), a nucleoside analog that can inhibit DNA cytosine methylation, possesses potent antitumorigenic activities for myeloid disorders. Although 5-Aza-CdR is known to be incorporated into DNA and inhibit DNA (cytosine-5)-methyltransferases, the precise mechanisms underlying the drug's antineoplastic activity remain unclear. Here we utilized a mass spectrometry-base...

Recent studies have shown high usage of the IGHV1-69 germline immunoglobulin gene for influenza hemagglutinin stem-directed broadly-neutralizing antibodies (HV1-69-sBnAbs). Here we show that a major structural solution for these HV1-69-sBnAbs is achieved through a critical triad comprising two CDR-H2 loop anchor residues (a hydrophobic residue at position 53 (Ile or Met) and Phe54), and CDR-H3-...

INTRODUCTION Osteoporosis and related fractures constitute a significant burden on modern healthcare. The standard method of diagnosing osteoporosis with a dual-energy X-ray absorptiometry (DXA) scan is limited by accessibility and expense. The thickness of the cortex of the proximal femur on plain radiographs has been suggested to be a method for indicating osteoporosis and as a risk factor of...

Synthetic peptides corresponding to eight individual heavy chain complementarity-determining regions (CDR) of three human monoclonal IgM anti-IgG (rheumatoid factor [RF]) paraproteins elicited rabbit antibodies with markedly different properties. All antisera recognized the immunizing peptide, and several reacted with the isolated IgM heavy chain on immunoblots. However, only the antisera again...

Tyrosine and glycine constitute 40% of complementarity determining region 3 of the immunoglobulin heavy chain (CDR-H3), the center of the classic antigen-binding site. To assess the role of D(H) RF1-encoded tyrosine and glycine in regulating CDR-H3 content and potentially influencing B cell function, we created mice limited to a single D(H) encoding asparagine, histidine, and arginines in RF1. ...

ADC-based receivers process the received data in the digital domain, eliminating the need for much of the analog front end. In addition, a feed-forward blind architecture [1,2] eliminates the feedback loop between digital and analog domains so that the ADC and digital CDR can be designed and simulated independently. Previous works [1,2] sampled the incoming data at 2 samples per UI and at 1.45 ...

ADC-based receivers process the received data in the digital domain, eliminating the need for much of the analog front end. In addition, a feed-forward blind architecture [1,2] eliminates the feedback loop between digital and analog domains so that the ADC and digital CDR can be designed and simulated independently. Previous works [1,2] sampled the incoming data at 2 samples per UI and at 1.45 ...