objective(s): we aimed to examine association of gene expression of mor1 and glun1 at mrna level in the lumbosacral cord and midbrain with morphine tolerance in male wistar rats. materials and methods: analgesic effects of morphine administrated intraperitoneally at doses of 0.1, 1, 5 and 10 mg/kg were examined using a hot plate test in rats with and without a history of 15 days morphine (10 mg...

background: the etiology of breast cancer and our understanding on the carcinogenicity of different risk factors is impotant for control programms. objective: we investigated the expression of estrogen and progesterone receptors (er, pr), and human epithelial receptor 2 (her2) overexpression and its associations, with environmental risk factors among breast cancer patients.  methods: we classif...

background: papillary thyroid carcinoma (ptc), occurs mostly in women and sex hormones may play a role in the pathogenesis and clinical course. the objective of this study was to determine the status and prevalence of estrogen and progesterone receptors in ptc with regard to age, gender, tumor size and lymph node involvement. methods: immunohistochemical stains were performed on 92 tissue block...

background: premenstrual dysphoric disorder (pmdd) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women. objective: the aim of this study was to investigate the association of dopamine d3 receptor ( drd3 ) polymorphism, and cannabinoid receptor type 1 ( cnr1 ) polymorphism with pmdd. materials and methods: fifty one participants with...

the purpose of the present study is to investigate the cytotoxicity/apoptotic effect of 2-chloro-2′-deoxyadenosine, cladribine, (2-cda) in the human breast cancer cell line, mda-mb468 (estrogen receptor negative, er−). mtt [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2h tetrazolium bromide] assay, annexin v-fluorescein/pi and hoechst 33258 staining were used to detect cytotoxicity and cell apopto...

Abstract Successful initiation of the B-cell receptor (BCR) signaling, and subsequent antigen-encounter in germinal centers are both marked by sharp increases CD25 surface-expression. Likewise, oncogenic signaling leukemia (B-ALL) lymphoma induces CD25-surface expression. While is known as an IL2-receptor chain on T- NK-cells, significance its expression B-cells was unclear. We discovered that,...

Abstract Cell-to-cell communication can be inferred from ligand–receptor expression in cell transcriptomic datasets. However, important challenges remain: global integration of cell-to-cell communication; biological interpretation; and application to individual population profiles. We develop ICELLNET, a transcriptomic-based framework integrating: 1) an original expert-curated database interact...

Trophoblast stem cells develop from polar trophoectoderm and give rise to the cells that generate the placenta. Trophoblast cells are responsible for the uterinal invasion and vascular remodeling during the implantation of the embryo. However this knowledge is not yet to be confirmed for trophoblast progenitor cells (TPCs). In this study, we aimed to demonstrate that human TPCs (hTPCs) express ...

There is no functional annotation for the majority of the several hundreds of receptor-like kinases in plants. A direct way of inferring the function of these proteins is to study the phenotype that results from loss of function mutants such as T-DNA mutant lines. In this research a function (phenotype) to At2g37050 gene that encodes a receptor like kinase in Arabidopsis T-DNA line was...