To the Editor: Hyperglycemia, a common feature in critically ill patients, was traditionally perceived as an adequate stress response reflecting the severity of the disease state and was treated only if glycemia exceeded 11–13.5 mmol/L. In recent studies in intensive care patients, we showed that tight glycemic control (TGC) with intensive insulin therapy (IIT) reduced the risk of organ failure...

OBJECTIVE The effect of long-term use of high glucose dialysate on peritoneal structure and function, and its relation with accumulation of advanced glycosylation end-product (AGE) in the peritoneum was investigated in this study. METHODS Dialysates with 4.25% glucose were injected into the peritoneal cavity of normal rats for 12 weeks without (PD, n = 7) and with (1 g/L, PD+AG, n = 7) aminog...

This study evaluated the single-pass system for the short-term dialysis treatment of dogs and cats with experimental renal failure. The hemodialyzer was equipped with a thin and highly permeable Cuprophan membrane. Four animals (two dogs and two cats) with total uretic obstruction were dialyzed twice in a one-week period. The vascular access by venipuncture of external jugular vein delivered mo...

Background: Identifying the sources of variation in QTc measurements is important for preventing arrhythmias during and after hemodialysis. The present study was designed to determine the correlation between the type of hemodialysis buffer and the changes in QTc interval in patients on chronic hemodialysis. Methods: Fifty-nine patients on chronic hemodialysis who referred in winter 2007 to hemo...

Drug delivery to the brain is highly restricted, since compounds must cross a series of structural and metabolic barriers to reach their final destination, often a cellular compartment such as neurons, microglia, or astrocytes. The primary barriers to the central nervous system are the blood-brain and blood-cerebrospinal fluid barriers. Through structural modifications, including the presence o...