Various 4'-hydroxy-3',5'-dinitro substituted chalcones 1 and S-benzylthiouronium chloride (SBT) 2 in the presence of DMF-organic bases (morpholine/ pyrrolidine/ piperidine) gave 4,6-diaryl-2-(4-morpholinyl / 1pyrrolidinyl /1-piperidinyl)pyrimidines 4, 5 and 6 in a facile one-pot conversion. In an another attempt reactants 1 and 2 yielded intermediate 2-benzylthiopyrimidines 3, in presence of DM...

Oxazine derivatives are an important class of heterocycles, which has attracted much synthetic interest due to their wide range of biological activities. Oxazine is a heterocyclic compound can be formally derived from benzene, and its reduction products, by suitable substitution of carbon (and hydrogen) atoms by nitrogen and oxygen. In the last few years, oxazine derivatives have proved to be v...

Aryl chalcones rearrange and add methanol to give substituted propane-1-ones upon UV-A irradiation in the presence of PPh3. We propose two possible mechanisms for this photo-rearrangement. The reaction involves either the formation of a phosphine-carbonyl intermediate, nucleophilic addition of MeOH and 1,2-aryl migration or the formation of ylide and carbene intermediates. The intermediates tra...

The compound Pyrazole derivatives, is prepared from p – Amino benzoic acid and ethanol. Chalcone has been prepared by the condensation reaction of Ethyl-4-acetamido benzoate and different ten aldehydes. These chalcones are cyclized with hydrazine hydrate and glacial acetic acid under reflux condition give pyrazole derivatives. These compounds have been characterized by detailed spectral analysi...

Flavonols, anthocyanins, and chalcones were determined during the flowering phase in two genotypes of Cosmos sulphureus (regular species its cultivar ‘Cosmic Orang’) grown М.М. Gryshko National Botanical Garden Kyiv. Inflorescences, leaves, stems, roots, separated ray disc florets dried crushed to prepare extracts following three different techniques. In particular, with 80 % (v/v) ethanol Andr...

Abstract: Background: Biocatalysis in organic solvents has several benefits over aqueous solvents, including solubility of substrates, ease workup, separation the product, and, certain cases, reusability biocatalysts. Materials and Methods: A simple, effective, environmentally friendly technique for synthesizing pyrazoles been established, which involves cyclo condensation chalcones isonicotini...