extracelllar matrix (ecm) materials from mammalian tissues have been broadly used for tissue engineering for animal models. while decellularization of tissues such as bladder, heart valve, knee meniscus and tendon has been performed, there are a few reports for articular cartilage. in this study we aimed to develop a technique to decellularize bovine articular cartilage as a biological construc...

In this study we examined enhancement effects of Artemisinin plus Glucantime and shark cartilage extract, on promastigotes and amastigotes of L.infantum in in vitro condition.The toxicity of artemisinin, glucantime and shark cartilage extract on the L. infantum promastigotes and amastigote-infected macrophages was evaluated using MTT assay. The role of these drugs in inducing apoptosis in proma...

Articular cartilage, the load-bearing tissue of the joint, has limited repair and regeneration ability. The scarcity of treatment modalities for large chondral defects has motivated researchers to engineer cartilage tissue constructs that can meet the functional demands of this tissue in vivo. Cartilage tissue engineering requires 3 components: cells, scaffold, and environment. ...

a dog was presented with history of progressive generalized subcutaneous emphysema and exercise intolerance secondary to dog fight. radiographic evaluation confirmed extensive subcutaneous emphysema, pneumomediastinum and pneumoretroperitoneum. surgical exploration revealed cricoid cartilage longitudinal fracture and cricotracheal detachment. the fractured cartilage was sutured and the cricoid ...

Our colleague, L. G. Parsons', has briefly outlined the historical facts regarding a disorder of the skeleton bearing the various names-hereditary deforming chondrodystrophy, multiple cartilaginous exostosis, diaphysial aclasis (Keith) or Ollier's disease; and Brailsford' has recorded the radiological details of a similar condition under the term chondro-osteodystrophy. The disease produces a s...

Objective(s) Articular cartilage tissue defects cannot be repaired by the proliferation of resident chondrocytes. Autologous chondrocyte transplantation (ACT) is a relatively new therapeutic approach to cover full thickness articular cartilage defects by in vitro grown chondrocytes from the joint of a patient. Therefore, we investigated the redifferentiation capability of human chondrocytes ma...

given the difficulties in accessing articular cartilage as a source of chondrocytes to be used in fabricating cartilage constructs, alternative sources are required. the present study examined chondrocytes from costal cartilage for their suitability in cartilage tissue engineering. chondrocytes isolated from rat knee and rib hyaline cartilage were separately mixed with alginate and placed in a ...

the capacity of mesenchymal stem cells (mscs) to differentiate among skeletal cell lineages and to undergo extensive proliferation in vitro renders them an appropriate source for cell-replacement therapy to heal defects of bone and cartilage tissue.it is argued that in bone and cartilage defects, mscs would better be transplanted as fully-differentiated cells otherwise they may produce non-spec...

INTRODUCTION There is a reciprocal relationship between tu mor agents and cellular differentiation. A particu lar agent may be introduced into only one type of differentiated or partially differentiated tissue. At the same time, an agent from a donor neoplasm will, when introduced into cells of a new host, not only induce rapid growth but also cause the host cells to become identical in appeara...