congenital malformation (cm) will begin to emerge as one of the major childhood health problems .treatment and rehabilitation of children with congenital malformations are costly and complete recovery is usually impossible. the aim of this study was to determine frequency of cm in yazd central city of the islamic republic of iran to find out if there has been any difference in the rate and type...

Background Selecting the best embryo for transfer, with the highest chance of achieving a vital pregnancy, is a major goal in current in vitro fertilization (IVF) technology. The high rate of embryonic developmental arrest during IVF treatment is one of the limitations in achieving this goal. Chromosomal abnormalities are possibly linked with chromosomal arrest and selection against abnormal fe...

Gastroschisis is a congenital anomaly which shows extra abdominal herniation of fetal bowel loops, occasionally with portions of liver/ stomach, into the amniotic cavity through a paraumbilical defect in the anterior abdominal wall. The defect is usually right sided. Gastroschisis is decreasing in incidence owing to early detection by the advanced techniques in imaging and more efficient and th...

PURPOSE Anorectal malformations are often associated with other anomalies, reporting frequency with 40-70%. Gastrointestinal anomalies have been known to be relatively less common than associated anomalies of other organ system. This study was performed to assess a distinctive feature of cases associated with esophageal atresia. METHODS Clinical data (from January 2000 through December 2011) ...

Objective: The purpose of this study is to show distribution of risk in pregnancies which underwent first trimester combined tests, and investigate general demographic and clinical characteristics of patients, underwent invasive diagnostic tests after screening tests. Methods: Combined test data of first trimester screening in 20082011 were evaluated retrospectively and cross-sectional. After t...

BACKGROUND The majority of cases of cerebral palsy (CP) have their pathogenesis during fetal development and are a form of congenital anomaly, the aetiology of which is uncertain. Anomalous development of other organs evident at birth is also a congenital anomaly. A small proportion of these are known to be caused by chromosomal or gene abnormalities, environmental teratogens and dietary defici...

Interstitial deletions of the long arm of chromosome 5 are among the most characteristic abnormalities observed in myeloid disorders. To assess the lineage involvement of peripheral blood cells from patients with a 5q--anomaly, purified neutrophils, monocytes, T lymphocytes, and B lymphocytes were analyzed for loss of heterozygosity using six different highly polymorphic mininucleotide and dinu...