congenital malformation (cm) will begin to emerge as one of the major childhood health problems .treatment and rehabilitation of children with congenital malformations are costly and complete recovery is usually impossible. the aim of this study was to determine frequency of cm in yazd central city of the islamic republic of iran to find out if there has been any difference in the rate and type...

Chromosomal defects are relatively frequent in infertile men however, translocations between the Y chromosome and autosomes are rare and less than 40 cases of Y-autosome translocation have been reported. In particular, only three individuals has been described with a Y;21 translocation, up to now. We report on an additional case of an infertile man in whom a Y;21 translocation was associated wi...

the anopheles stephensi mysorensis originating from kazeroon area south of iran, which had been maintained at the laboratory conditions of at 70% relative humidity for almost 150 generations, were subjected to cytogenetical analyses. the ‘instant’ landmarks in the squash preparations of the salivary gland chromosomes are indicative of cytotaxonomic characteristics of the species. the characteri...

We identified the telomere length at different hematological phases in 16 patients with myelodysplastic syndromes (MDS), showing disease evolution with a conventional Southern blot hybridization using the (TTAGGG)4 probe. The MDS patients studied were classified into three groups according to the pattern of telomere length reduction. The first group had telomere shortening at the time of diseas...

It is now well recognised that the fragile X chromosome anomaly is associated with certain cases of X linked mental retardation.'-3 The fragile site is usually seen as an isochromatid gap at the interface of the long arm bands Xq27 and Xq28. However, we have observed that the fragile X is also frequently manifested as a deleted X chromosome with loss of the distal long arm band, q28 (figure). T...

Atypical chronic myeloid leukemia (aCML) is a rare leukemic disorder with no specific genetic lesion. Here we demonstrate clonal occurrences of tetrasomy for the long arm of chromosome 21 in a patient with aCML, and a thorough review of the literature provides evidence that this chromosomal anomaly is a so far not recognised recurrent finding in aCML. Further, the timely association of the occu...

This report concerns a woman who experienced a relapse of acute lymphoblastic leukemia (ALL) associated with an interstitial deletion of the long arm of chromosome 6 in donor cells more than 4 years after allogeneic bone marrow transplantation (BMT). Direct bone marrow preparations revealed the presence of two leukemic clones 46,XY,del(6)(q23q25) and 45,X,-4,del(6)(q23q25),+8,-15,-21,+i(21q), +...