The aim of the study was to analyze the association between chronic cholecystitis, premalignant lesions and gallbladder cancer. The group consisted in 3901 cases of cholecystectomies, diagnosed as acute cholecystitis (250 cases - 6.4%), chronic cholecystitis (3619 cases - 92.8%) and gallbladder carcinoma (32 cases - 0.8%). Chronic cholecystitis associated premalignant lesions as follows: hyperp...

Base excision repair (BER) pathway is one of the repair systems that have an impact on the radiotherapy and chemotherapy for the cancer patients. The molecular pathogenesis of gallbladder cancer is not known extensively. In the present study we investigated whether the expression of AP endonuclease 1 (APE1) and DNA polymerase β (DNA pol β), key enzymes of BER pathway has any clinical ...

In the early stages of gestation changes in lipid peroxidation can lead to violations regulatory and protective functions biomembranes pregnant women. The objective: study concentration intermediate final products LPO during first trimester patients with miscarriage against background chronic diseases hepatobiliary system. Materials methods. 118 women (7-10 weeks), aged 22 - 39 y. o. (mean age ...

The new coronavirus infection (COVID-19) is a life-threatening condition. features of the treatment COVID-19 in pregnant women are not sufficiently studied and contradictory, therefore, research this area relevant. Objective . Assess presence liver disease with during pregnancy after childbirth, taking into account treatment. Methods A retrospective analysis medical records 43 aged 19 to 39 yea...