In this article, a semi-analytical solution is provided to investigate the free vibration characteristics of rotating truncated conical shells surrounded by Winkler–Pasternak type foundation. It assumed that material shell composed epoxy as matrix and graphene nanoplatelets (GPLs) reinforcement dispersed in both thickness length directions shell. The modeled based on first-order shear deformati...

The continual reassessment method (CRM) is a sequential design used in phase I cancer trials to determine the maximal dose with acceptable toxicity. It has been established that the CRM is consistent under model misspecification but not generally. When the method does not converge to the target percentile, some dose-response models will be more sensitive than others in terms of how close the co...

The continual reassessment method (CRM) is a commonly used dose-finding design for phase I clinical trials. Practical applications of this method have been restricted by two limitations: (1) the requirement that the toxicity outcome needs to be observed shortly after the initiation of the treatment; and (2) the potential sensitivity to the prespecified toxicity probability at each dose. To over...

Love-type wave generation in a fiber-reinforced medium placed over an inhomogeneous orthotropic half-space is analysed. The upper and lower boundary surfaces of the fiber reinforced medium are periodically corrugated. Inhomogeneity of half-space is caused by variable density and variable shear modules. Displacement components for layer and half-space are derived by applying separable variable t...

BACKGROUND We evaluated scar lesions after initial and repeat catheter ablation of atrial fibrillation (AF) and correlated these regions to low-voltage tissue on repeat electroanatomic mapping. We also identified gaps in lesion sets that could be targeted and closed during repeat procedures. METHODS AND RESULTS One hundred forty-four patients underwent AF ablation and received a delayed-enhan...

The amplitude of sound scattered from submerged elastic objects is dominated by resonance phenomena corresponding to the mechanical eigenvibrations of the object. It is often difficult to predict the resonance frequencies of bounded elastic targets using exact methods. It has been shown, however, that resonances arise due to phase matching of circumferential waves traveling over the object surf...

background and aims. the aim was to evaluate the effect of three methods of fiber insertion on fracture resistance of root-filled maxillary premolars in vitro. materials and methods. sixty extracted human maxillary premolars received endodontic treatment followed by preparation of mesioocclusodistal (mod) cavities, with gingival cavosurface margin 1.5 mm coronal to the cementoenamel junction (c...

Peristaltic transport of an incompressible electrically conducting viscous fluid in an inclined planar asymmetric channel is studied. The asymmetry is produced by choosing the peristaltic wave train on the walls to have different amplitude and phase. The closed form solutions of momentum and energy equation in presence of viscous dissipation term are obtained for long wave length and low Reynol...

Supravalvular aortic stenosis (SVAS) is associated with decreased elastin and altered arterial mechanics. Mice with a single deletion in the elastin gene (ELN(+/-)) are models for SVAS. Previous studies have shown that elastin haploinsufficiency in these mice causes hypertension, decreased arterial compliance, and changes in arterial wall structure. Despite these differences, ELN(+/-) mice have...

BACKGROUND Mitral stenosis (MS) is still the most common complication of acute rheumatic fever in Turkey. Rheumatic carditis affects not only cardiac valves but also myocardium. In this study, we aimed to evaluate the subclinical left ventricular (LV) systolic dysfunction and contraction of short and long axial circumferential and longitudinal fibers by pulsed wave tissue Doppler in rheumatic M...