The inhibitory effects of vitamin D on colitis have been previously documented. Global vitamin D receptor (VDR) deletion exaggerates colitis, but the relative anticolitic contribution of epithelial and nonepithelial VDR signaling is unknown. Here, we showed that colonic epithelial VDR expression was substantially reduced in patients with Crohn's disease or ulcerative colitis. Moreover, targeted...

BACKGROUND AND AIMS Those who have had an appendicectomy have a reduced risk of developing ulcerative colitis. However, the effect of appendicectomy on disease activity in patients with ulcerative colitis has not been established. METHODS We used the Danish National Patient Registry to identify all incident cases of ulcerative colitis in Denmark during the period 1981 to 1999. Of these, 202 h...

AIMS To assess the value of histology in diagnosing inflammatory bowel disease (IBD) in colorectal biopsy specimens. METHODS Retrospective, double blind evaluation of colorectal biopsy specimens from 41 patients with colitis (28 with ischaemic colitis and 13 with acute self-limited colitis) and 84 patients with IBD (42 with Crohn's disease and 42 with ulcerative colitis). RESULTS The featur...

Chronic diarrhoea is a frequent complaint in clinical practice. Microscopic colitis is the cause of this symptom in 10% of these cases and the prevalence is rising. To exclude microscopic colitis a colonoscopy with multiple biopsies of different regions of the colon is mandatory. A sigmoidoscopy alone is insufficient. Two histopathological types of microscopic colitis can be distinguished: coll...

Evidence that CD4(+) regulatory T cells can control Ag-specific CD8(+) T cell-mediated colitis in immunocompetent mice is poorly documented. To examine the potential of CD4(+) T cells to control colitis, we used our model of CD8(+) T cell-mediated colitis induced by intracolonic sensitization followed by challenge with the hapten 2,4-dinitrobenzene sulfonic acid. The defect of CD4(+) T cells in...

Ischemic colitis is a popular diagnosis suggesting sudden hypo-perfusion of the colon. Pathophysiology of this illness has not been resolved clearly. Most of ischemic colitis is a one time disease and do not need specific treatment and recover self-limitedly under only bowel rest. Ischemic colitis sometimes exist with viral infection, this therefore necessitated the need to analyze the relation...

BACKGROUND IL-23/IL-23R signaling plays a pivotal role during the course of inflammatory bowel diseases (IBD). However, the underlying mechanisms are poorly characterized. Foxp3+ regulatory T cells are critical in the maintenance of gut immune homeostasis and therefore are important in preventing the development of IBD. This study was performed to clarify the association between IL-23/IL-23R si...

A case of pyostomatitis vegetans and ulcerative colitis in a 26-year-old African is described. The colitis, confirmed clinically and radiologically, antedated the development of pyostomatitis. Systemic corticosteroids apparently cured the pyostomatitis but only caused an improvement in the ulcerative colitis. The rarity of ulcerative colitis amongst the Nigerian population and of pyostomatitis ...

Acute limb ischemia is rare in patients with venous thromboembolism who already receive anticoagulation treatment. Inflammation a risk factor for thrombus formation. Patients active ulcerative colitis, especially at the time of exacerbation, are more prone to thromboembolism, both and arterial. The thrombosis 18% higher, higher bleeding. To date, there no contraindication any anticoagulant drug...