The colorectal cancer (CRC) is a most frequent cause of cancer-related deaths. Surgical tumor resection remains the primary curative treatment for CRC but nearly 50% of patients with macroscopic clearance of the tumor by surgery relapses. For this purpose new complementary treatments, such as immunotherapy, are being explored. In this article, we analyze and discuss the clinical immunotherapy v...

Colorectal cancer (CRC) holds the woeful record of being the most preventable but least prevented type of cancer. Although healthy lifestyles and screening programs associated to early polyp removal greatly reduce CRC incidence and CRC-related death, the overall lack of information and of effective preventive policies is promoting an overwhelming global escalation of this disease. Moreover, new...

aim : leptin is a 16 kda polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (crc). leptin exerts its effect through the leptin receptor (lepr) a member of the class i cytokine receptor family. background : we have investigated whether glutamine to a...

Familial adenomatous polyposis (FAP) is responsible for <1% of colorectal cancer (CRC) cases and is inherited as an autosomal dominant trait. Patients generally present hundreds to thousands of adenomas and develop colorectal cancer by age 35- 40 if left untreated. Here we report four patients with germline frameshift mutation (small deletion) at exon 15 of adenomatous polyposis coli (APC) tumo...

BACKGROUND Associations between family history of colorectal cancer (CRC) in first degree relatives and risk of developing cancer have been well defined, but interactions with environmental, lifestyle and dietary factors are much less clear. AIM The aim of this study was to evaluate family history, lifestyle and dietary factors associated with developing colorectal cancer in an Arab populatio...

BACKGROUND The risk of colorectal cancer (CRC) and breast cancer (BC) is influenced by polymorphisms located in the genes encoding enzymes of the folate pathway. The aim of this study was to evaluate if A66G MTRR (rs1801394) polymorphism is involved in predisposition for colorectal and breast carcinogenesis in Romanian patients. MATERIALS AND METHODS In the present case-control study, 300 ind...

BACKGROUND AND OBJECTIVES Although there was growing evidence supporting the hypothesis that Notch1 was one of the few candidate genes linked with colorectal cancer (CRC) susceptibility, the precise level of Notch1 protein expression in benign and malignant colorectal diseases was still unknown. Our study has investigated the Notch1 expression in benign and malignant colorectal diseases as well...

AIM Social media (SM) can provide information and medical knowledge to patients. Our aim was to review the literature and web-based content on SM that is used by Colorectal Cancer (CRC) patients, as well as surgeons' interaction with SM. METHOD Studies published between 2006 and 2016 were assessed. We also assessed the impact of several hashtags on Twitter with a freeware (Symplur). RESULTS...

Colorectal cancer (CRC) is the third most common diagnosed malignancy in the world and is the second leading cause of cancer death in developed countries (Rebecca et al., 2012). Colorectal cancer is the fourth leading cause of cancer and cancer related deaths among both men and women in Turkey. Distant metastasis is the main cause of death in CRC patients. The liver is the most frequent (approx...

Colorectal neoplasm is considered to have a strong association with nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS), respectively. The relationship among NAFLD, MetS, and colorectal neoplasm was assessed in 1793 participants. Participants were divided into 4 groups based on the status of NAFLD and MetS. Relative excess risks of interaction (RERI), attributable proportion ...