background & aim: low back pain is the most debilitating condition, and can lead to decreased physical function, compromised quality of life, and psychological distress. several studies have been conducted to recognize the risk factors of low back pain, but despite of strong relationship between obesity and low back pain, the underlying mechanisms are unclear. the aim of this study was to evalu...

Background & Aim: Low back pain is the most debilitating condition, and can lead to decreased physical function, compromised quality of life, and psychological distress. Several studies have been conducted to recognize the risk factors of low back pain, but despite of strong relationship between obesity and low back pain, the underlying mechanisms are unclear. The aim of this study wa...

BACKGROUND Mesenchymal stem cells (MSCs) are viewed as a having significant potential for tissue engineering and regenerative medicine therapies. Clinical implementation of MSCs, however, demands that their preparation be stable and reproducible. Given that environmental and bioprocessing parameters such as substrate stiffness, seeding densities, culture medium composition, and mechanical loadi...

PURPOSE Traditional chemotherapy is the main adjuvant therapy for the treatment of non-small cell lung cancer (NSCLC). However, the emergence of multi-drug resistance (MDR) has greatly restricted the curative effect of chemotherapy. Therefore, it is necessary to find a method to treat MDR NSCLC clinically. It is worth investigating whether NSCLCs that are resistant to traditional chemotherapy c...

Objective(s) Using a cancer murine model of invasive aspergillosis (IA), we investigated the expression of TLR-2, Dectin-1 and the level of cytokine production by CD4+ T helper cells in different groups of mice (with or without cancer), also, the effect of invasive aspergillosis on the immune response pattern of cancer mice. Materials and Methods Patterns of susceptibility and resistance to ...

Objective: The autoimmune diseases tend to coexist with diabetes mellitus type I (T1DM). The concomitance of these two types of diseases will lead to poor glycemic control beside their own complications. In this study the prevalence of thyroid disorder and celiac disease among T1DM patients in Yazd, Iran was evaluated. Materials and Methods: all the patients diagnosed as T1DM in Yazd younger t...

Abstract The effect of hyperbaric storage (HS) on polyphenoloxidase activity (PPO) was studied in model solutions and apple juice. Model containing increasing amounts mushroom ( Agaricus bisporus ) PPO (up to 26 U) were stored at room temperature pressure up 200 MPa. During HS, samples assessed for residual activity. enzyme completely inactivated according a first-order kinetic that used calcul...