PURPOSE To determine whether differentiating corneal epithelium can temporally stimulate fibroblast activity. METHODS Corneal epithelial cells were cultured to confluence and then stimulated to mature into multilayered epithelia with addition of serum-containing medium. Differentiation was assessed morphologically and immunocytochemically using a monoclonal antibody to cytokeratin 3. At inter...

We tested the hypothesis that cytokines derived from differentiated skeletal muscle cells in culture induce neutrophil chemotaxis after mechanical strain. Flexible-bottom plates with cultured human muscle cells attached were exposed to mechanical strain regimens (ST) of 0, 10, 30, 50, or 70 kPa of negative pressure. Conditioned media were tested for the ability to induce chemotaxis of human blo...

Miss Havisham and Magwitch, who lead tragic life but adopt different manners of the mechanism projection-egoistic manner altruistic manner, bring about large distinction between their methods education exert vital influences on Estella’s Pip’s fates in Great Expectations written by Charles Dickens. This paper aims to analyze impact ego’s defence represented projection education. Besides analyzi...

Abstract not available Northern International Medical College Journal Vol. 12 No.1 July 2020, Page 484-485

Large polyarenes with unusually complex structures can be obtained in a straightforward manner from commercially available starting materials, by means of aryne chemistry. This approach involves a sequence of tandem reactions that can be performed in one pot to give sterically congested chiral aromatic hydrocarbons that adopt highly twisted conformations.

Drug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viability in prostate cancer cells on treatment with chemotherapeutic drugs. Co-culture with prostate CAF...