Herein, 1F2, an anti-HER2 monoclonal antibody (mAb), was covalently coupled to the surface of 5-Fluorouracil (5-FU) loaded bovine serum albumin (BSA) nanoparticles. Concerning two different crosslinkers for conjugation of 1F2, Maleimide-poly (ethylene glycol)-Succinimidyl carbonate (Mal-PEG5000-NHS) was selected due to its higher conjugation efficiency (23±4 %) obtained in comparison to N-succi...

Herein, 1F2, an anti-HER2 monoclonal antibody (mAb), was covalently coupled to the surface of 5-Fluorouracil (5-FU) loaded bovine serum albumin (BSA) nanoparticles. Concerning two different crosslinkers for conjugation of 1F2, Maleimide-poly (ethylene glycol)-Succinimidyl carbonate (Mal-PEG5000-NHS) was selected due to its higher conjugation efficiency (23±4 %) obtained in comparison to N-succi...

Abstract The coupled MODFLOW-HYDRUS software package was used to produce a saturated-unsaturated flow model for a Flood Spreading System (FSS) and its associated aquifer. The study aim to improve simulations of near-surface hydrological processes, including temporal and spatial variation in groundwater recharge rates. The coupled model was built with average RMSE=1.1 and 1.3 for calibration ...

In present study, a mathematical model of the vehicle–floating slab track (FST) interaction is established to investigate the coupled behaviour of vehicle–track system. The FST is modelled as the double Euler -Bernoulli beam including the rail and slab. The railway vehicle is simplified as a multi-rigid-body model. The wheel–rail interface is treated using a nonlinear Hertzian contact model, co...

In this article our objective is to obtain steady state characteristics of shunt, series, and separately excited DC motors coupled with a centrifugal water pump supplied through a step-up, step-down, and cuk converter from photovoltaic generator. We assume that there are no storage batteries and, of course, the system must operate on maximum utilization i.e. maximum water must be pumped. It is ...

This study shows the design of a new hybrid power generation system, photovoltaic panel (PV)–coupled solid oxide fuel cell (SOFC) and gas turbine (GT)–electrolyser. Three objectives (cost, pollutant emissions, and reliability), which are usually in conflict, are considered simultaneously. The design of a hybrid system, considering the three mentioned objectives, poses a very complex problem of o...

we calculate the stopping power for heavy-ion diclusters moving in a strongly coupled two-dimensional electron gas system by using the local field corrected dielectric function at finite temperature. we obtain a parameterized local field correction factor based on a relation between the thermal compressibility and exchange-correlation energy in two-dimension. the interpolated parameter is deriv...

  The primary characteristic of an Ultra-Large-Scale (ULS) system is ultra-large size on any related dimension. A ULS system is generally considered as a system-of-systems with heterogeneous nodes and autonomous domains. As the size of a system-of-systems grows, and interoperability demand between sub-systems is increased, achieving more scalable and dynamic access control system becomes an im...