نتایج جستجو برای: cyclooxygenase
تعداد نتایج: 15217 فیلتر نتایج به سال:
Aspirin-induced asthma is a distinct clinical syndrome which affects about 10% of adult asthmatics. In these patients aspirin and several other analgesics precipitate asthmatic attacks. The idea that the attacks might result from the specific inhibition of a single enzyme, namely cyclooxygenase, has gained both experimental and clinical support. It stimulated a number of hypotheses on the mecha...
Background and Objective: Triterpenes could exert anti-inflammatory properties. The aim of this study was to evaluate the inhibitory activities of cycloartan triterpene derivatives extracted from Euphorbia with names as cycloartan-24-methylene3-ol(1), cycloartan-23-ene-3,25-diol(2), cycloartan-23-ene-25-methoxy-3-ol (3) and cycloartan-24-ene-3-ol (4) on cyclooxygenase-1(cox-1) activity. Mate...
Abstract Background: Two types of Cyclooxygenase enzymes, which produce prostaglandins, are present in humans. Prostaglandins play a role in the functions of various organs including the immune system, blood circulation, and cell division. Reports indicate that the level of these enzymes is increased in patients with metastases in several malignancies, including larynx, lung, stomach, colon, an...
The enzyme cyclooxygenase-2 (COX-2), responsible for the first committed step in the synthesis of several important mediators which are involved in both initiation and resolution of inflammation, and the subsequent generation of prostaglandins (PGs) upon activation has been shown to participate in the neurodegenerative processes of a variety of diseases. This review looks particular at the role...
Studies of ferriheme cyclooxygenase, using two different assay systems, show that a variety of peroxides can trigger a rapid acceleration of cyclooxygenase activity to produce prostaglandins. Lipid hydroperoxides formed by lipoxygenase were the most potent activators tested, followed by prostaglandin Gz, which was slightly less potent. Peroxides nonspecifically generated during arachidonate aut...
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