introduction: endodontic sealers are in direct contact with periradicular tissues and play a critical role in regeneration and pathogenesis of periradicular diseases. the aim of this study was to compare cytotoxicity of four different types of sealers including ah plus, sankin, tubliseal ewt and apexit as well as their effect on cytokine release of l929 fibroblasts. materials and methods: in th...

The biological application of nanoparticles (NPs) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. The cytotoxicity was evaluated by MTT and LDH assays. The apoptotic effect of free ICD-85 and ICD-85 NPs on HeLa cells was assessed using caspase-8 colorimetric assay. The MTT assay showed that ICD-85 NPs could enhance the in-vitro cyt...

Aims The purpose of this study was to determine the cell viability and cytotoxicity of various endocytosis and efflux inhibitors which can be used to determine transport and uptake mechanisms in the BeWo (b30 clone) human placental trophoblast cell line. Ethanol and dimethylsulfoxide (DMSO) were also studied since they are often used as cosolvents for administration of these inhibitors. Metho...

The L. is also used as a crude medicament that mostly effected in various neurological and immunological disorders. It known Ashwagandha “Indian ginseng” Indian region. There lack of information on the possible neuroprotective properties W. somnifera root against HO- Ab(1-42)-induced cytotoxicity, which are now targeted for innovative treatments dementia, particularly dementia Alzheimer's type ...

Exposure to pollutants is considered one of the potential reasons population declines in bats. In context previous studies, we managed create and keep a wide collection cell lines from European bat species. Liver cells were chosen for testing, as they represent preferred model toxicological studies. Bats are protected, replacing experimental animals thus unique opportunity examine effects which...

Background: Cadmium is one of the most toxic heavy metals in our environment having a very strong ability to accumulate in body organs, especially in kidney. The present study was done to determine the genotoxicity and cytotoxicity in kidneys of rats exposed to cadmium. Methods: Male rats (n=30), kept in standard conditions were used in this study. The animals were randomly divided into 2 group...

Background:  Cisplatin has cytotoxic effects through free radical generation. Reports indicate that various members of Pinaceae family may have antioxidant properties. In this study we investigated the cytoprotective effects of needle volatile oil and bark extract of Pinus eldarica in hepatoma G2 (HepG2) cell line.  Methods: Using the maceration technique, we obtained the ethanolic extract of ...

Cancer is one of the main causes of mortality. Therapeutic importance in some diseases, especially cancers has led to considering the anti-cancer effects of probiotics more than ever. Probiotics have stimulatory effects on the immunity and suppressor effects on cancer activity. Various studies report that probiotic bacteria have cytotoxicity effects on different types of solid tumors. In this r...