BACKGROUND AND OBJECTIVE The aim of this study is to observe the changes of MMP-2 and its regulators, and to investigate the mechanism of the two administration sequences of recombinant human endostatin (rh-endostatin) and docetaxel. METHODS The experiment was performed as 2 stages. Firstly, nude mice with xenograft tumor were randomized into 2 groups as rh-endostatin-treated group with rh-en...

The influence of Large Woody Debris (LWD) and tributary confluences on the grain size distributions of a mountainous stream network in the Western Cascades was analyzed. Longitudinal Trends in grain sizes were determined to be increasing with downstream distance. The influences that LWD and tributary confluences have on these trends were investigated using spatial and bivariate correlations. Th...

AE23A‐01 presented at 2010 Fall Meeting, AGU, San Francisco,Calif., 13–17 Dec.Maslowski, G., and V. A. Rakov (2006), A study of the lightning channelcorona sheath, J. Geophys. Res. , 111 , D14110, doi:10.1029/2005JD006858.Miki, M., V. A. Rakov, K. J. Rambo, G. H. Schnetzer, and M. A. Uman(2002), Electric fields near triggered lightning channels measured withpockels s...

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Eftilagimod alpha (EF) is a soluble LAG-3 protein (LAG-3Ig) that binds to subset of MHC class II molecules and mediates activation antigen-presenting cells followed by T-cells. AIPAC investigated EF + paclitaxel (PA). We hereby report exploratory biomarker multivariate analyses. This double-blinded, 1:1 randomized phase IIb trial enrolled pts with HR+ HER2- MBC. Pts received PA (80 mg/m2 IV on ...

Introduction: Despite aggressive surgery, radiotherapy and chemotherapy, malignant gliomas remain fatal. As these tumors are highly angiogenic, therapies directed against tumor vasculature or preventing angiogenesis have been developed. Monitoring changes in structural and functional microvasculature should help to evaluate the efficiency of these therapies. Previous results suggest that MRI fo...

A key question for a Chief Information Officer (CIO) would be the future run-time cost and performance of complex business application software, before deciding to migrate it to a cloud. It is difficult for CIOs to accurately estimate cloud cost and performance in a fast and inexpensive manner. In this article, we describe “Silverlining”, a simulator for estimating the cost and performance of a...

This study aimed to investigate the diagnostic performance of trace apparent diffusion coefficient (tADC) maps in prostate cancer (PCA) detection at different spatial resolutions and number of averages (NAV), and to determine a practical protocol that could provide satisfactory diagnostic performance for PCA detection. The tADC maps were reconstructed into three different isotropic resolutions,...

The mined ecotype of Sedum alfredii Hance has been identified to be a zinc (Zn) hyperaccumulator native to China. In the present article, the characteristics of cadmium (Cd) uptake and accumulation were compared with hydroponic experiments between the mined and the nonmined ecotypes of Sedum alfredii Hance. The results indicate that the plants of the mined ecotype (ME) have higher tolerance of ...