Alcoholism is a frequent comorbidity following mild traumatic brain injury (mTBI), even in patients without a previous history of alcohol dependence. Despite this correlational relationship, the extent to which the neurological effects of mTBI contribute to the development of alcoholism is unknown. In this study, we used a rodent blast exposure model to investigate the relationship between mTBI...

the aim of this animal study was to evaluate the possible effects of carbonated soft drink consumption on the rate of orthodontic tooth movement in rats.thirty-six adult male sprague-dawley rats were randomly divided into two experimental groups and one control group. in the experimental groups (a&b;), the water in the dietary regimen was replaced with soft drinks (fanta® in group a and cola® i...

The transgenic rat TGR(mRen2)27 is a new monogenetic model in hypertension research that develops fulminant hypertension after the mouse Ren-2d renin gene has been integrated into its genome. To evaluate the molecular mechanism of development of hypertension in this animal model, we measured cytosolic free sodium concentration in intact lymphocytes from seven transgenic rats and eight age-match...

Ingestion of MDMA ("ecstasy") by humans can cause acute toxicity manifested by hyperthermia and death. Demethylenation of MDMA is catalyzed by cytochrome P-450 2D6 (CYP2D6) and cytochrome P-450 2D1 (CYP2D1) in humans and rats, respectively, and is polymorphically expressed. It has been proposed that CYP2D6 deficiency may account for the unexplained toxicity of MDMA. The female Dark Agouti rat i...

Background: Individually, green tea and coffee have been extensively studied for mitigation of metabolic syndrome (MS) in both rats humans; however, their combined effect requires further investigation. Thus, we compared the combining decaffeinated light roasted on MS rats. Methods: An animal model was constructed by feeding Spragu...

Purpose: To study the effect of berberine on serum hormonal levels, endometrial gene, and protein signaling in a rat model polycystic ovary syndrome (PCOS).Methods: Eighty-seven healthy female Sprague Dawley (SD) rats were assigned to control group, PCOS each with 29 rats. The three groups: control, model, groups, A was established via administration letrozole (1 mg/kg) group continuously for 2...

Purpose: To further evaluate the safety of Fuganlin Oral Liquid (FGLOL) for clinical application by conducting toxicological tests in young rats.
 Methods: Based on dose infants aged less than 1 year, 4-day-old Sprague-Dawley (SD) rats were orally administered FGLOL3.88, 11.64 and 38.75 g crude drug/kg 18 days, followed a 3-week withdrawal. This was evaluating effect FGLOL various growth d...

The spared nerve injury (SNI) model of neuropathic pain was first developed by Decosterd and Woolf in 2000 in Sprague Dawley rats to enhance reproducibility of injury and behavioral responses resulting from a partial nerve injury. Given the differences in methodology and inconsistent behavioral data published in the SNI model of neuropathic pain in mice, and given that interspecies behavioral c...

Previously we demonstrated that kidney concentration and urinary excretion of angiotensin-(1-7) are increased during normal pregnancy in rats. Since this finding may reflect local kidney production of angiotensin-(1-7), we determined the immunocytochemical distribution of angiotensin-(1-7) and its newly described processing enzyme, ACE2, in kidneys of virgin and 19-day-pregnant Sprague-Dawley r...

The objective of this study was to examine whether ultrasound can the development cerebral vascular structure and blood flow in Sprague–Dawley (SD) rats by a noninvasive manner, which provides reference for research SD rats. Thirty-nine (7–16 days old) were divided into seven groups according age, number each group was, respectively, 7, 17, 1, 3, 2, 8, 1. Ultrasound used detect vessels, cerebro...