the deleterious effects of morphine sulphate addiction on the central nervous system are welldocumented. previous studies have shown that the passage of morphine from the placenta barrier caninfluence the normal development of embryos, such as those of humans, by specific mechanisms. so, forthe first time, for the purpose of investigating the effects of morphine sulphate on pregnant animals,thr...

Anti-apoptotic and antioxidant effects of melatonin protect spleen whole body ?-irradiated male Sprague-dawley rats

Male and female Sprague-Dawley rats reared in social isolation and in crowded conditions were tested on their active-avoidance performance. Only males appeared to be affected by the treatments; no housing-condition effect was found on the performance of females. The most severe housing-condition effect was that of social isolation; the isolated males showed impaired acquisition of the avoidance...

Male Sprague-Dawley rats ranging in age from 20 to 110 days were injected with two doses of morphine sulphate, and examined for behavioral activation and catalepsy. Behavioral activation increased with age, while sensitivity to catalepsy declined. Ontogenetic and pharmacological responses suggest possible separate mediation of activation and catalepsy.

Purpose: We aimed to investigate dragon fruit (Hylocereus polyrhizus) extract effectiveness by creating a nephropathy model with contrast media toxicity after dehydration and furosemide administration rats. 
 Methods: Total 36 male Sprague dawley rats were randomly allocated into 6 groups (n: 6). At the end of experiment kidney organs blood was taken for histopathologic biochemical analyze...

RATIONALE MDMA alters body temperature in rats with a direction that depends on the ambient temperature (TA). The thermoregulatory effects of MDMA and TA may affect intravenous self-administration (IVSA) of MDMA but limited prior reports conflict. OBJECTIVE To determine how body temperature responses under high and low TA influence MDMA IVSA. METHODS Male Sprague-Dawley rats were trained to...

Aim: The intent of the study was to assess bone conserving effect Butea monosperma total extract (BTE) prepared from stem-bark, in ovariectomy (Ovx)-induced loss Sprague Dawley (SD) rats.
 Methods: Sprague-Dawley rats were ovariectomized (Ovx) and BTE treatment with three different doses (100mg, 250mg 500mg/kg body weight) commenced a day after Ovx continued for 12 weeks. Skeletal paramete...