The vehicle routing with pickups and deliveries (VRPD) problem is de6ned over a graph G=(V; E). Some vertices in G represent delivery customers who expect deliveries from a depot, and other vertices in G represent pickup customers who have available supply to be picked up and transported to a depot. The objective is to 6nd a minimum length tour for a capacitated vehicle, which starts at a depot...

OBJECTIVE Nonadherence is a major challenge in schizophrenia treatment. While long-acting (depot) antipsychotic medications are often recommended to address adherence problems, evidence on the comparative effectiveness of depot versus oral antipsychotics is inconsistent. We hypothesize that this inconsistency could be due to systematic differences in study design. This review evaluates the effe...

PURPOSE OF REVIEW The major problem with the oral formulation of naltrexone for heroin dependence is poor compliance (adherence). Long-acting sustained release formulations of naltrexone (implantable and injectable) might help to improve compliance and, thus, increase the efficacy of abstinence-oriented treatment of heroin dependence with naltrexone. RECENT FINDINGS There have been several im...

This paper deals with a real-life vehicle delivery routing problem, which is a seafood product delivery routing problem. Considering the features of the seafood product delivery routing problem, this paper formulated this problem as a multi-depot open vehicle routing problem. Since the multi-depot open vehicle routing problem is a very complex problem, a method is used to reduce the complexity ...

Last-mile delivery in the logistics chain contributes to congestion urban networks due frequent stops. Crowd-shipping is a sustainable and low-cost alternative traditional but relies heavily on availability of occasional couriers. In this work, we propose crowd-shipping system that uses depots improve accessibility for potential crowd-shippers serve large portion demand small parcels. While sma...

1 Introduction On the Dispatching Problem Federico Di Miele Giorgio Gallo October 18, 2000 Most often, space is the scarce resource in Bus Depots located in congested urban areas: vehicles arriving at the end of their trips are packed together in a rather small space. That implies that, when a vehicle has to leave to start a new trip, most often, other vehicles have to be moved to clear the way...

Abstract This paper develops new solution procedures for the order picker routing problem in U-shaped picking zones with a movable depot, which has so far only been solved using simple heuristics. The presents first exact approach, based on combinatorial Benders decomposition, as well heuristic approach dynamic programming that extends idea of venerable sweep algorithm. In computational study, ...

OBJECTIVE Non-adherence is a major problem in the treatment of schizophrenia. Depot antipsychotic drugs are thought to reduce relapse rates by improving adherence, but a systematic review of long-term studies in outpatients is not available. METHOD We searched the Cochrane Schizophrenia Group's register, ClinicalTrials.gov, Cochrane reviews on depot medication, and the reference sections of i...

among numerous np-hard problems, the traveling salesman problem (tsp) has been one of the most explored, yet unknown one. even a minor modification changes the problem’s status, calling for a different solution. the generalized traveling salesman problem (gtsp)expands the tsp to a much more complicated form, replacing single nodes with a group or cluster of nodes, where the objective is to fi...