This research focused on using design of experiments (DoE) and simulation modeling to optimize the facility layout in a server assembly line, while introducing a new product. The critical factors that impact the performance metrics of cycle time, work-in-process and throughput were identified by using DoE principles. Subsequently, simulation modeling was used to evaluate the various what-if sce...

This expository paper discusses the relationships among metamodels, simulation models, and problem entities. A metamodel or response surface is an approximation of the input/output function implied by the underlying simulation model. There are several types of metamodel: linear regression, splines, neural networks, etc. This paper distinguishes between fitting and validating a metamodel. Metamo...

Formulated products are complex mixtures of ingredients whose time to market can be difficult speed due the lack general predictable physical models for desired properties. Here, we report coupling a machine learning classification algorithm with Thompson sampling efficient multiobjective optimization (TSEMO) simultaneous continuous and discrete outputs. The methodology is successfully applied ...

Children have often been treated as small adults in relation to drug formulation, but research has now shown this not be the case. Therefore, there is a push from regulatory bodies provide formulations specifically tailored towards needs of fragmented population. Orally dissolving films (ODFs) identified an emerging opportunity, bridge gap. aim study was prepare ODFs containing topiramate, anti...

This paper presents a robust control design for variable speed control of a two-bladed horizontal axis wind turbine similar to the DOE MOD-0 model. Robustness is achieved by introducing a sign term to the dynamic error. To simulate numerical experiments that closely approximate the reality, a dynamic oscillator is employed as a source of a time varying wind speed signal.

Design of Experiments (DoE) is a powerful guiding tool that can help researchers to identify the main variables that affect the performance characteristics. The present paper elaborates on the optimization and prediction of reaction parameters like type of plastic, catalyst, and temperature using Taguchi’s L9 orthogonal array method with three levels and three parameters to obtai...