For functional neuroimaging studies of stuttering, two challenges are (1) the elicitation of naturally stuttered versus fluent speech and (2) the separation of activation associated with abnormal motor execution from activation that reflects the cognitive substrates of stuttering. This paper reports on a proof-of-concept study, in which a single-subject approach was applied to address these two...

As the articles comprising this special issue amply demonstrate, brain functional imaging is having a significant impact on research in persistent developmental stuttering (PDS). Specifically, voxel-wise statistical parametric images (SPI) demonstrating differences in the brain activation patterns evoked by fluent versus stuttered speech are having an impact. The first such report (Fox et al., ...

We present a 69 year-old man with hypertension who developed the sudden onset of horizontal binocular diplopia and stuttering of speech. On examination, bilateral exotropia (i.e. 'wall-eyed') was observed in the primary position. Attempted horizontal saccades revealed bilateral internuclear ophthalmoplegia; all consistent with the wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndro...

Title of Document: GENETIC STUDIES OF STUTTERING IN A LARGE WEST AFRICAN FAMILY Bailey Levis, MS, 2006 Directed By: Associate Professor, Sarah Tishkoff, Department of Biology A large family of West African origin displaying persistent developmental stuttering was ascertained. This family contains 106 individuals, 45 of whom display the phenotype. A genome wide scan was conducted using 366 micro...

Area 44 is a cytoarchitectonically distinct portion of Broca's region. Parallel and overlapping large-scale networks couple with this region thereby orchestrating heterogeneous language, cognitive, and motor functions. In the context of stuttering, area 44 frequently comes into focus because structural and physiological irregularities affect developmental trajectories, stuttering severity, pers...