Based on the accurate identification of chemical structures as electric elements, we described charge transport mechanism in a DNA molecule by a stepwise LC oscillatory circuitry, in which every base pair is a capacitor, every phosphate bridge is an inductor, and every deoxyribose is a charge router. The circuit model agrees with established experimental evidence that has supported super-exchan...

Conjugation of an anthracycline to a triplex-forming oligonucleotide (TFO) allows delivery of this drug to a specific DNA site, preserving the intercalation geometry of this class of anticancer agents. Conjugate 11, in which the TFO is linked via a hexamethylene bridge to the O-4 on the D ring of the anthraquinone moiety, affords the most stable triple helix, through intercalation of the planar...

1Journal paper no. J-17200 of the Iowa Agric. and Home Econ. Exp. Sta., Ames. Project no. 3184. The authors express their appreciation to R. Larson, J. Helm, and J. Newton for DNA collection and isolation. Contribution of PiGMaP DNA by PiGMaP laboratories is appreciated. This work was supported in part by the EC Bridge “PiGMaP” program and the Iowa Agric. and Home Econ. Exp. Sta., Ames. 2Presen...

DNA double-strand breaks (DSBs) can be repaired by one of two major pathways-non-homologous end-joining (NHEJ) and homologous recombination (HR)-depending on whether cells are in G1 or S/G2 phase, respectively. However, the mechanisms of DSB repair during M phase remain largely unclear. In this study, we demonstrate that transient treatment of M-phase cells with the chemotherapeutic topoisomera...

Ever since the middle of the last centurywhen Sir Charles Wheatstone first put to practical use a curious electrical balancing network which had been devised a decade before by a fellow Englishman named Christie, the bridge circuit has been accepted a s avaluable and powerful tool in the field of electrical measurement. Even though today bridges, like almost everything else, have become increas...

This paper presents an induced voltage linear extraction method for disturbing force self-sensing in the application of giant magnetostrictive actuators (GMAs). In this method, a Kelvin bridge combined with an active device is constructed instead of a conventional Wheatstone bridge for extraction of the induced voltage, and an additional GMA is adopted as a reference actuator in the self-sensin...

Bacteria and their associated bacteriophages are in a continuous battle, co-evolving defence, offence mechanisms. Bacterial xenogeneic silencers, H-NS family proteins, play important roles bacterial phage defence evolution by silencing incoming genes acquired through horizontal gene transfer. It is anticipated that the repression of these directly dependent on DNA binding modes proteins. protei...

artemisinin and its derivatives are very important new class of antimalarial drugs. one of the most important artemisinin derivatives is artemether. the antiparasitic activity of artemether as a derivative of artemisinin is related to endoperoxide bridge in its structure. the aim of this study was the evaluation of antileishmanial effect of artemether, with more focus on its apoptotic effect. i...

This paper reports on the analysis of the signals sent by accelerometers fixed on the axles of a vehicle which passes over a bridge. The length of the bridge is divided into some parts and the transmissibility measurement is applied to the signals recorded by two following instrumented axles. As the transmissibility procedure is performed on the divided signals, the method is called Short Time ...

Although DNA methylation was originally thought to only affect transcription, emerging evidence shows that it also regulates alternative splicing. Exons, and especially splice sites, have higher levels of DNA methylation than flanking introns, and the splicing of about 22% of alternative exons is regulated by DNA methylation. Two different mechanisms convey DNA methylation information into the ...