A functioning gene drive system could fundamentally change our strategies for the control of vector-borne diseases by facilitating rapid dissemination of transgenes that prevent pathogen transmission or reduce vector capacity. CRISPR/Cas9 gene drive promises such a mechanism, which works by converting cells that are heterozygous for the drive construct into homozygotes, thereby enabling super-M...

Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, SBS-B1n-27, 60 Nanyang Drive, Singapore 637551; School of Biological Sciences, Nanyang Technological University, SBS-B2n-27, 60 Nanyang Drive, Singapore 637551; National University of Singapore (NUS)-The Hebrew University of Jerusalem (HUJ), Mechanisms of Inflammation, Campus for Research Excellence ...

Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Here we identify causes underlying hybrid infertility of two recently diverged fission yeast species Schizosaccharomyces pombe and S. kambucha, which mate to form viable hybrid diploids that efficiently complete meiosis, but generate few viable gametes. We find that chromoso...

A direct-drive arm is a mechanical arm in which the shafts of articulared joints are directly coupled to the rotors of motors with high torque. Since the arm does not contain transmission mechanisms between the motors and their loads, the drive system has no backlash, small friction, and high mechanical stiffness, all of which are desirable for fast, accurate, and versatile robots. First, the p...