Pharmacokinetic and pharmacodynamics principles are fundamental to achieving the optimal response to antiretroviral drug therapy: successful antiretroviral therapy depends on attaining a therapeutic drug concentration that maximizes efficacy and minimizes toxicity.[1] Understanding drug interactions plays an important role for clinicians in providing effective and safe antiretroviral therapy. D...

Swellable-core technology (SCT) formulations that used osmotic pressure and polymer swelling to deliver drugs to the GI tract in a reliable and reproducible manner were studied. The SCT formulations consisted of a core tablet containing the drug and a water-swellable component, and one or more delivery ports. The in vitro and in vivo performance of two model drugs, tenidap and sildenafil, formu...

BACKGROUND While global maternal mortality declined 44 % between 1990 and 2015, the majority of countries fell short of attaining Millennium Development Goal targets. The Sustainable Development Goals (SDGs), adopted in late 2015, include a target to reduce national maternal mortality ratios (MMR) to achieve a global average of 70 per 100,000 live births by 2030. A comprehensive paper outlining...

1Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, University of Sana’a, Yemen. ABSTRACT This study in 3 districts of Hajjah governorate, Yemen, used WHO core indicators to investigate irrational prescribing of antimalarial drugs in public and private health facilities. Laboratory diagnosis rates were low in public facilities (21.2% of encounters). Informal p...

THE CONSULTANT PHARMACIST JUNE 2003 VOL. 18, NO. 6 Although it has been a core component of consultant pharmacy practice for more than 30 years, drug regimen review (DRR) continues to evolve to accommodate many new additions to the increasingly complex medication armamentarium, and the changing needs of long-term care patient populations. In the first article in this three-part series, we explo...

terbutaline sulfate exhibits extensive first pass metabolism and a short elimination half life which makes frequent oral administration of the drug inevitable. a novel buccoadhesive controlled delivery system of the drug can easily overcome the problem. a two-layered core tablet composed of a fast release layer made of mannitol, lactose, peg and the drug attached to a sustained release layer co...