glutathione s-transferases (gsts; ec: 2.5.1.18) are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. functional genetic polymorphisms in genes encoding gstm1 (a member of gst class mu; omim: 138350), and gstt1 (a member of gst class theta; omim: 600436) have been well defined. the functional null alleles of gstm1 and gstt1 represent deletions of gstm1 and gs...

chemokines and their receptors  play an important  role in the  late inflammatory stage of asthma. in this study, we aimed to investigate polymorphisms of mcp-1 (ccl2), ccr2 and ccr5 which can affect qualitatively and/or quantitatively their production and thus influence both susceptibility and severity of asthma and its clinical and biological features. mcp-1   (a/g   -2518),  ccr2   (+/64i), ...

OBJECTIVE Insulin resistance and the apolipoprotein (apo) allele e4 have both been associated with coronary heart disease (CHD). We examined the relationship between insulin resistance and apo(e) polymorphisms among participants in the Framingham Offspring Study. RESEARCH DESIGN AND METHODS During 1991-1995, subjects underwent a clinical examination and an oral glucose tolerance test with mea...

BACKGROUND AND PURPOSE The progression of migraine into chronic daily headache involves multiple risk factors, but the main contributor is not known. Glutamate is the major excitatory neurotransmitter in central sensitization, which is an important process in the pathogenesis of migraine transformation. The glutamate transporter protein excitatory amino acid transporter 2 (EAAT2) is the primary...