INTRODUCTION Fractional exhaled nitric oxide (FeNO) is considered as a useful, noninvasive marker of airway inflammation in asthma and allergic rhinitis. It has also been suggested that anti-inflammatory treatment guided by monitoring of exhaled NO could improve overall asthma control. However, long-term intra-subject variability of this parameter as well as the rate of its change, which can be...

STUDY OBJECTIVES The present study introduces a method that has been developed to improve the remote collection and transportation of gas samples from the nose and lungs. DESIGN Assessment of agreement between two methods of clinical measurements. SETTING Noninvasive exhaled gas measurement at a respiratory research laboratory. PARTICIPANTS Ten nonsmoking adult volunteers (median age, 44 ...

Carbon monoxide is a product of haem degradation by haem oxygenase (HO), activated by inflammatory cytokines and oxidants. This study examined whether allergen challenge can increase exhaled CO levels, as a reflection of HO activation. Exhaled CO and nitric oxide, an expired gas also thought to reflect cytokine-induced airway inflammation, were measured in 15 atopic steroid-naive nonsmoking pat...

Bradykinin (BK) is a mediator of inflammation in asthma with potent bronchoconstrictor actions. Endogenous release of nitric oxide may inhibit BK-induced bronchoconstriction. This study investigated whether bradykinin inhalation could modulate exhaled NO levels in normal and asthmatic subjects, and whether the bradykinin-induced effects were mediated through the production of cyclo-oxygenase pr...

Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, anti-inflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is r...

The aim of the present study was to see whether measurements of airway hyperresponsiveness (AHR) and nitric oxide (NO) in exhaled air (ENO) either separately or in combination, could differentiate between asthmatics and healthy control subjects in a population based survey. In central Norway 8,571 adolescents participated in a large-scale epidemiological survey (Young Helseundersøkelsen i Nord-...

Cystic fibrosis affects multiple organs but lung disease remains the major determinant of patient morbidity and mortality. Cystic fibrosis lung disease is characterized by chronic infection and inflammation. The amino acid L-arginine is substrate for both nitric oxide synthases and arginases. The activity of arginase in sputum is increased while the production of nitric oxide is reduced in the ...

BACKGROUND Nitric oxide is important in vasomotor regulation. Contamination of anaesthetic gases with nitric oxide could affect gas exchange. METHODS We measured oxygenation and nitric oxide concentrations in the inspiratory and expiratory limb of the ventilator circuit in patients about to have cardiac surgery. Measurements were made before surgery when the circulation and respiratory condit...

This study was designed to assess the effect of differential leukocyte depletion during chemotherapy by monitoring the levels of exhaled hydrogen peroxide H2O2 and nitric oxide (F(eNO)) present. In 39 patients with lung cancer (chronic obstructive pulmonary disorder up to stage II, median forced expiratory volume in one second 78% predicted), measurements were performed before a cycle of therap...

Exhaled nitric oxide (NO) concentration is a noninvasive measure of airway inflammation and is increased in asthma. Inhaled glucocorticoids decrease exhaled NO concentration, but the relative contributions of alveolar and bronchial levels to the decrease in exhaled NO concentration are unknown. Alveolar NO concentration and bronchial NO flux can be separately approximated by measuring exhaled N...