this study aimed to identify the relationship between fractional exhaled nitric oxide (feno) level and potential factors in non-asthmatic children from shanghai, china. from march to april 2012, the school-aged children fulfilling the inclusion criteria were recruited. the feno levels of non-asthmatic children were detected by the nano coulomb nitric oxide analyzer. questionnaires were recorded...

BACKGROUND Fractional exhaled nitric oxide is elevated in allergen-provoked asthma. The cellular and molecular source of the elevated fractional exhaled nitric oxide is, however, uncertain. OBJECTIVE To investigate whether fractional exhaled nitric oxide is associated with increased airway epithelial inducible nitric oxide synthase (iNOS) in allergen-provoked asthma. METHODS Fractional exha...

allergic rhinitis and asthma share common  epidemiological features and inflammatory processes. the aim of the present study was to document the influence of natural allergen exposure in exhaled no  (eno)  and in spirometric parameters of patients with seasonal allergic rhinitis(sar) and to investigate the differences among subjects with positive versus negative bronchial provocation to metacho...

RATIONALE Nitric oxide formation is deficient in airways of patients with cystic fibrosis (CF). Since nitric oxide has bronchodilatory effects, nitric oxide deficiency may contribute to airway obstruction in CF. OBJECTIVES We reasoned that inhalation of l-arginine, the precursor of enzymatic nitric oxide formation, could improve airway nitric oxide formation and pulmonary function in patients...

BACKGROUND Exhaled nitric oxide has been proposed as a marker for airway inflammation in asthma. The aim of this study was to compare exhaled nitric oxide levels with inflammatory cells and mediators in bronchoalveolar lavage fluid from asthmatic and normal children. METHODS Children were recruited from elective surgical lists and a non-bronchoscopic bronchoalveolar lavage (BAL) was performed...

With respect to the ambient nitric oxide values, we have examined their effect on exhaled nitric oxide. Since there was no significant influence of ambient nitric oxide levels ,20 ppb on the fraction of exhaled nitric oxide values in our study population (figs 2 and 3), we decided to include all children with ambient nitric oxide levels ,20 ppb in the analyses. When the analyses were repeated, ...

Cytokines such as tumour necrosis factor-alpha and interferon gamma are associated with active pulmonary inflammation in sarcoidosis and they upregulate inducible nitric oxide synthase (iNOS). The objectives of this study were to examine iNOS upregulation in sarcoidosis by showing raised exhaled nitric oxide and increased iNOS activity in lung biopsy specimens of these patients utilizing immuno...

INTRODUCTION Asthma is a chronic respiratory disease characterized by hyper-responsiveness and bronchial inflammation. The bronchial inflammation in these patients can be monitored by measuring the fractional exhaled nitric oxide. This study aims to determine fractional exhaled nitric oxide association with peak expiratory flow and with asthma control inferred by the Global Initiative for Asthm...

BACKGROUND Exhaled nitric oxide is a non-invasive marker of airway inflammation and a portable analyser, the NIOX MINO (Aerocrine AB, Solna, Sweden), is now available. This study aimed to assess the reproducibility of the NIOX MINO measurements across age, sex and lung function for both absolute and categorical exhaled nitric oxide values in two distinct groups of children and teenagers. METH...

BACKGROUND There is a lack of objective measures of the clinical efficacy of allergen immunotherapy which relies on patients' perception about the effect of this treatment. We studied whether the fraction of exhaled nitric oxide is affected by multiple allergen immunotherapy in polysensitized adult subjects with allergic rhinitis. We also looked for associations between exhaled nitric oxide and...