نتایج جستجو برای: experimental autoimmue encephalomyelitis model

تعداد نتایج: 2637440  

Journal: :AJNR. American journal of neuroradiology 1988
M A Kuharik M K Edwards M R Farlow G J Becker B Azzarelli E C Klatte G T Augustyn R G Dreesen

Experimental allergic encephalomyelitis, a demyelinating disease with marked similarity to multiple sclerosis, was produced in two of 12 dogs. All dogs were studied with serial MR imaging. T1- and T2-weighted MR images were obtained both before and after IV Gd-DTPA. Multiple, new periventricular white matter demyelinating lesions were observed after each clinical episode of the disease. Like mu...

2017
Joshua N. Lorbach Leyi Wang Jacqueline M. Nolting Madonna G. Benjamin Mary Lea Killian Yan Zhang Andrew S. Bowman

Acute outbreaks of respiratory disease in swine at agricultural fairs in Michigan, USA, in 2015 raised concern for potential human exposure to influenza A virus. Testing ruled out influenza A virus and identified porcine hemagglutinating encephalomyelitis virus as the cause of influenza-like illness in the affected swine.

2003
LESTER S. KING

The pathology of the nervous system in equine encephalomyelitis has been described for both the Western (1) and the Eastern (2) forms of the disease. Much attention has been paid to the intranuclear inclusion bodies, found in glial and mesodermal cells as well as in neurones. The intense inflammation, together with the necrosis of nerve cells, has been reported. I t is the purpose of this paper...

Journal: :The Journal of Experimental Medicine 2001
Eric S. Huseby Denny Liggitt Thea Brabb Bryan Schnabel Claes Öhlén Joan Goverman

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterized by plaques of infiltrating CD4(+) and CD8(+) T cells. Studies of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, focus on the contribution of CD4(+) myelin-specific T cells. The role of CD8(+) myelin-specific T cells in mediating EAE or MS has not been described pr...

Journal: :Neuropeptides 2011
J Luis Quintanar Eva Salinas Andrés Quintanar-Stephano

It has been reported that the spinal cord possesses Gonadotropin-releasing hormone (GnRH) receptor and that GnRH has neurotrophic properties. Experimental autoimmune encephalomyelitis (EAE) causes neurodegeneration in spinal cord. Thus, the present study was designed to determine whether administration of GnRH reduces the severity of EAE. The clinical signs of locomotion, axonal morphometry and...

Journal: :PPAR Research 2008
Paul D. Drew Jihong Xu Michael K. Racke

The role of peroxisome proliferator-activated receptors (PPARs) in altering lipid and glucose metabolism is well established. More recent studies indicate that PPARs also play critical roles in controlling immune responses. We and others have previously demonstrated that PPAR-gamma agonists modulate the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple ...

2012
Francesco Mannara Tony Valente Josep Saura Francesc Graus Albert Saiz Beatriz Moreno

Experimental autoimmune encephalomyelitis (EAE) is the most relevant animal model to study demyelinating diseases such as multiple sclerosis. EAE can be induced by active (active EAE) or passive (at-EAE) transfer of activated T cells in several species and strains of rodents. However, histological features of at-EAE model in C57BL/6 are poorly described. The aim of this study was to characteriz...

Journal: :International immunology 1997
R Liblau L Steinman S Brocke

Experimental autoimmune encephalomyelitis (EAE) in an inflammatory demyelinating disease which usually follows a monophasic course. Autoreactive Th1 CD4+ T cells are responsible for the lesions, whereas autoreactive Th2 CD4+ T cells can, upon adoptive transfer, suppress the disease process. However, the role of IL-4 and Th2 cells in the spontaneous remission of EAE and in the prevention of rela...

Journal: :Therapeutic advances in neurological disorders 2012
Marie Cathrin Mayer Edgar Meinl

B cells and antibodies constitute an important element in different inflammatory diseases of the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify disease subgroups and may in addition contribute to the pathogenic process. One candidate autoantigen for multiple sclerosis (MS) is myelin oligodendrocyte glycoprotein (MOG). MOG is localized at the outermost surface ...

Journal: :The Journal of Experimental Medicine 1999
Kimberly A. Sabelko-Downes Anne H. Cross John H. Russell

We have previously demonstrated a role for Fas and Fas ligand (FasL) in the pathogenesis of experimental allergic encephalomyelitis (EAE). However, using an active induction paradigm we could not distinguish between FasL expressed on activated CD4(+) T cells from that expressed on other inflammatory or resident central nervous system (CNS) cells. To address this issue, we have conducted recipro...

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